Molecular strategies for the utilisation of human milk oligosaccharides by infant gut-associated bacteria

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dc.contributor.authorKiely, Leonie Janeen
dc.contributor.authorBusca, Kizkitzaen
dc.contributor.authorLane, Jonathan A.en
dc.contributor.authorvan Sinderen, Douween
dc.contributor.authorHickey, Rita M.en
dc.contributor.funderTeagascen
dc.contributor.funderH & H Group, Irelanden
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2023-11-22T10:11:27Z
dc.date.available2023-11-22T10:11:27Z
dc.date.issued2023en
dc.description.abstractA number of bacterial species are found in high abundance in the faeces of healthy breast-fed infants, an occurrence that is understood to be, at least in part, due to the ability of these bacteria to metabolize human milk oligosaccharides (HMOs). HMOs are the third most abundant component of human milk after lactose and lipids, and represent complex sugars which possess unique structural diversity and are resistant to infant gastrointestinal digestion. Thus, these sugars reach the infant distal intestine intact, thereby serving as a fermentable substrate for specific intestinal microbes, including Firmicutes, Proteobacteria, and especially infant-associated Bifidobacterium spp. which help to shape the infant gut microbiome. Bacteria utilising HMOs are equipped with genes associated with their degradation and a number of carbohydrate-active enzymes known as glycoside hydrolase enzymes have been identified in the infant gut, which supports this hypothesis. The resulting degraded HMOs can also be used as growth substrates for other infant gut bacteria present in a microbe-microbe interaction known as ‘cross-feeding’. This review describes the current knowledge on HMO metabolism by particular infant gut-associated bacteria, many of which are currently used as commercial probiotics, including the distinct strategies employed by individual species for HMO utilisation.en
dc.description.sponsorshipTeagasc (Walsh Scholarship 2020212)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKiely, L.J., Busca, K., Lane, J.A., van Sinderen, D. and Hickey, R.M. (2023) ‘Molecular strategies for the utilisation of human milk oligosaccharides by infant gut-associated bacteria’, FEMS Microbiology Reviews, 47(6), fuad056 (18pp). doi: 10.1093/femsre/fuad056en
dc.identifier.doi10.1093/femsre/fuad056en
dc.identifier.endpage18en
dc.identifier.issn1574-6976en
dc.identifier.issued6en
dc.identifier.journaltitleFEMS Microbiology Reviewsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15254
dc.identifier.volume47en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.ispartofFEMS Microbiology Reviewsen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© The Author(s) 2023. Published by Oxford University Press on behalf of FEMS. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectHuman milk oligosaccharidesen
dc.subjectPrebioticsen
dc.subjectInfant gut microbiotaen
dc.subjectProbioticsen
dc.subjectBifidobacteriaen
dc.subjectLactobacillusen
dc.titleMolecular strategies for the utilisation of human milk oligosaccharides by infant gut-associated bacteriaen
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
oaire.citation.issue6en
oaire.citation.volume47en
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