Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

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dc.contributor.authorBoland, Barryen
dc.contributor.authorYu, Wai Haungen
dc.contributor.authorCorti, Olgaen
dc.contributor.authorMollereau, Bertranden
dc.contributor.authorHenriques, Alexandreen
dc.contributor.authorBezard, Erwanen
dc.contributor.authorPastores, Greg M.en
dc.contributor.authorRubinsztein, David C.en
dc.contributor.authorNixon, Ralph A.en
dc.contributor.authorDuchen, Michael R.en
dc.contributor.authorMallucci, Giovanna R.en
dc.contributor.authorKroemer, Guidoen
dc.contributor.authorLevine, Bethen
dc.contributor.authorEskelinen, Eeva-Liisaen
dc.contributor.authorMochel, Fannyen
dc.contributor.authorSpedding, Michaelen
dc.contributor.authorLouis, Carolineen
dc.contributor.authorMartin, Olivier R.en
dc.contributor.authorMillan, Mark J.en
dc.contributor.funderInstitut de Recherches Servieren
dc.date.accessioned2024-06-05T07:40:00Z
dc.date.available2024-06-05T07:40:00Z
dc.date.issued2018-08-17en
dc.description.abstractNeurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis represent a major socio-economic challenge in view of their high prevalence yet poor treatment. They are often called 'proteinopathies' owing to the presence of misfolded and aggregated proteins that lose their physiological roles and acquire neurotoxic properties. One reason underlying the accumulation and spread of oligomeric forms of neurotoxic proteins is insufficient clearance by the autophagic–lysosomal network. Several other clearance pathways are also compromised in NDAs: chaperone-mediated autophagy, the ubiquitin–proteasome system, extracellular clearance by proteases and extrusion into the circulation via the blood–brain barrier and glymphatic system. This article focuses on emerging mechanisms for promoting the clearance of neurotoxic proteins, a strategy that may curtail the onset and slow the progression of NDAs.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBoland, B., Yu, W., Corti, O. et al. (2018) 'Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing', Nature Reviews Drug Discovery, 17, pp. 660–688. https://doi.org/10.1038/nrd.2018.109en
dc.identifier.doihttps://doi.org/10.1038/nrd.2018.109en
dc.identifier.eissn1474-1784en
dc.identifier.endpage688en
dc.identifier.issn1474-1776en
dc.identifier.journaltitleNature Reviews Drug Discoveryen
dc.identifier.startpage660en
dc.identifier.urihttps://hdl.handle.net/10468/15983
dc.identifier.volume17en
dc.language.isoenen
dc.publisherSpringer Natureen
dc.rights© 2018, Springer Nature Ltd. All rights reserved. This is a post-peer-review, pre-copyedit version of an article published in Nature Reviews Drug Discovery. The final authenticated version is available online at: https://doi.org/10.1038/nrd.2018.109en
dc.subjectNeurodegenerative disorders of ageing (NDAs)en
dc.subjectNeurotoxic proteinsen
dc.titlePromoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageingen
dc.typeArticle (peer-reviewed)en
oaire.citation.issue9en
oaire.citation.volume17en
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