dc.contributor.author	Mangifesta, Marta
dc.contributor.author	Mancabelli, Leonardo
dc.contributor.author	Milani, Christian
dc.contributor.author	Gaiani, Federica
dc.contributor.author	de’Angelis, Nicola
dc.contributor.author	de’Angelis, Gian Luigi
dc.contributor.author	van Sinderen, Douwe
dc.contributor.author	Ventura, Marco
dc.contributor.author	Turroni, Francesca
dc.contributor.funder	Science Foundation Ireland	en
dc.date.accessioned	2019-10-02T04:40:22Z
dc.date.available	2019-10-02T04:40:22Z
dc.date.issued	2018-09-18
dc.description.abstract	The human intestine retains a complex microbial ecosystem, which performs crucial functions that impact on host health. Several studies have indicated that intestinal dysbiosis may impact on the establishment of life-threatening intestinal diseases such as colorectal cancer. An adenomatous polyp is the result of abnormal tissue growth, which is benign but is considered to be associated with a high risk of developing colorectal cancer, based on its grade of dysplasia. Development of diagnostic tools that are based on surveying the gut microbiota and are aimed at early detection of colorectal cancer represent highly desirable target. For this purpose, we performed a pilot study in which we applied a metataxonomic analysis based on 16S rRNA gene sequencing approach to unveil the composition of microbial communities of intestinal polyps. Moreover, we performed a meta-analysis involving the reconstructed microbiota composition of adenomatous polyps and publicly available metagenomics datasets of colorectal cancer. These analyses allowed the identification of microbial taxa such as Faecalibacterium, Bacteroides and Romboutsia, which appear to be depleted in cancerogenic mucosa as well as in adenomatous polyps, thus representing novel microbial biomarkers associated with early tumor formation. Furthermore, an absolute quantification of Fusubacterium nucleatum in polyps further compounded the important role of this microorganism as a valuable putative microbial biomarker for early diagnosis of colorectal cancer.	en
dc.description.sponsorship	GenProbio; MIUR	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.articleid	13974	en
dc.identifier.citation	Mangifesta, M., Mancabelli, L., Milani, C., Gaiani, F., de’Angelis, N., de’Angelis, G.L., van Sinderen, D., Ventura, M. and Turroni, F., 2018. Mucosal microbiota of intestinal polyps reveals putative biomarkers of colorectal cancer. Scientific reports, 8(1),(13974). DOI:10.1038/s41598-018-32413-2	en
dc.identifier.doi	10.1038/s41598-018-32413-2	en
dc.identifier.eissn	2045-2322
dc.identifier.endpage	9	en
dc.identifier.issued	1	en
dc.identifier.journaltitle	Scientific Reports	en
dc.identifier.startpage	1	en
dc.identifier.uri	https://hdl.handle.net/10468/8668
dc.identifier.volume	8	en
dc.language.iso	en	en
dc.publisher	Nature Publishing Group	en
dc.relation.project	info:eu-repo/grantAgreement/EC/H2020::CSA/696300/EU/The second coordination and support action for the JPI Healthy Diet for a Healthy Life/CSA JPI HDHL 2.0	en
dc.relation.uri	https://www.nature.com/articles/s41598-018-32413-2
dc.rights	© The Author(s) 2018	en
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	en
dc.subject	Human intestine	en
dc.subject	Intestinal dysbiosis	en
dc.subject	Colorectal cancer	en
dc.subject	Life-threatening intestinal diseases	en
dc.title	Mucosal microbiota of intestinal polyps reveals putative biomarkers of colorectal cancer	en
dc.type	Article (peer-reviewed)	en

Mucosal microbiota of intestinal polyps reveals putative biomarkers of colorectal cancer

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