Short-term treatment of metformin and glipizide on oxidative stress, lipid profile and renal function in a rat model with diabetes mellitus

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dc.contributor.authorAbdel-Moneim, A. M. H.
dc.contributor.authorLutfi, M. F.
dc.contributor.authorAlsharidah, A. S.
dc.contributor.authorShaker, G.
dc.contributor.authorFaisal, Waleed
dc.contributor.authorAbdellatif, A. A. H.
dc.contributor.authorAl Rugaie, O.
dc.contributor.authorMohany, K. M.
dc.contributor.authorEid, S. Y.
dc.contributor.authorEl-Readi, M. Z.
dc.contributor.authorAlsharidah, M.
dc.contributor.funderQassim Universityen
dc.date.accessioned2022-06-14T11:16:03Z
dc.date.available2022-06-14T11:16:03Z
dc.date.issued2022-02-15
dc.date.updated2022-06-09T10:33:52Z
dc.description.abstractBackground: Oxidative stress, lipid profile and renal functions are well-known conventional risk factors for diabetes mellitus (DM). Metformin and gliclazide are popularly used monotherapy drugs for the treatment of DM. Aims: This study aims to assess the short-term treatment of single and dual therapy of glipizide/metformin on oxidative stress, glycemic control, serum lipid profiles and renal function in diabetic rats. Methods: DM was induced in rats with streptozotocin (STZ), then five different treatments were applied, including group I (untreated healthy control), group II (diabetic and untreated), group III (diabetic and treated with metformin), group IVI (diabetic and treated with glipizide) and group V (diabetic and treated with a combination of metformin and glipizide. Lipid peroxidation (LPO), nitric oxide (NO), total antioxidant capacity (TAC), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), creatinine and urea were measured. Results: Compared to the untreated DM group, FBG and HbA1c were significantly reduced in the DM groups (p < 0.01) treated with metformin (159.7 mg/dL & 6.7%), glipizide (184.3 mg/dL & 7.3%) and dual therapy (118 mg/dL & 5.2%), respectively. Treatment with dual therapy and metformin significantly decreased LPO and NO levels but increased TAC in diabetic rats more than glipizide compared to untreated diabetic rats. Furthermore, metformin (19.8 mg/dL, p < 0.001), glipizide (22.7 mg/dL, p < 0.001), and dual therapy (25.7 mg/dL, p < 0.001) significantly decreased urea levels in the treated rats compared to untreated DM rats (32.2 mg/dL). Both drugs and their combination exhibited a substantial effect on total cholesterol, HDL, LDL and atherogenic index. Conclusions: These results suggest that the therapeutic benefits of metformin and glipizide are complementary. Metformin exhibited superior performance in improving glycemic control and decreasing oxidative stress, while glipizide was more effective against dyslipidemia. These findings could be helpful for the treatment of future vascular patients, antilipidemic medicines and antioxidant therapy to improve the quality of lifeen
dc.description.sponsorshipQassim University (Deanship of Scientific Research)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid2019en
dc.identifier.citationAbdel-Moneim, A.-M.H.; Lutfi, M.F.; Alsharidah, A.S.; Shaker, G.; Faisal, W.; Abdellatif, A.A.H.; Rugaie, O.A.; Mohany, K.M.; Eid, S.Y.; El-Readi, M.Z.; Alsharidah, M. (2022) ‘Short-Term Treatment of Metformin and Glipizide on Oxidative Stress, Lipid Profile and Renal Function in a Rat Model with Diabetes Mellitus’, Applied Sciences, 12 (4), 2019, (17 pp). doi: 10.3390/app12042019en
dc.identifier.doi10.3390/app12042019en
dc.identifier.endpage17en
dc.identifier.issn2076-3417
dc.identifier.issued4en
dc.identifier.journaltitleApplied Sciences-Baselen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/13296
dc.identifier.volume12en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urihttps://www.mdpi.com/2076-3417/12/4/2019
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectDiabetes mellitusen
dc.subjectGlipizideen
dc.subjectLipid profileen
dc.subjectMetforminen
dc.subjectOxidative stressen
dc.subjectRenal functionen
dc.titleShort-term treatment of metformin and glipizide on oxidative stress, lipid profile and renal function in a rat model with diabetes mellitusen
dc.typeArticle (peer-reviewed)en
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