Small intestinal bacterial overgrowth in children: A state-of-the-art review
| dc.contributor.author | Avelar Rodriguez, David | |
| dc.contributor.author | Ryan, Paul M. | |
| dc.contributor.author | Toro Monjaraz, Erick Manuel | |
| dc.contributor.author | Ramirez Mayans, Jaime Alfonso | |
| dc.contributor.author | Quigley, Eamonn M. | |
| dc.date.accessioned | 2019-10-06T21:39:04Z | |
| dc.date.available | 2019-10-06T21:39:04Z | |
| dc.date.issued | 2019-09-04 | |
| dc.description.abstract | Small intestinal bacterial overgrowth (SIBO) is a heterogenous and poorly understood entity characterised by an excessive growth of select microorganisms within the small intestine. This excessive bacterial biomass, in turn, disrupts host physiology in a myriad of ways, leading to gastrointestinal and non-gastrointestinal symptoms and complications. SIBO is a common cause of non-specific gastrointestinal symptoms in children, such as chronic abdominal pain, abdominal distention, diarrhoea, and flatulence, amongst others. In addition, it has recently been implicated in the pathophysiology of stunting, a disease that affects millions of children worldwide. Risk factors such as acid-suppressive therapies, alterations in gastrointestinal motility and anatomy, as well as impoverished conditions, have been shown to predispose children to SIBO. SIBO can be diagnosed via culture-dependant or culture-independent approaches. SIBO's epidemiology is limited due to the lack of uniformity and consensus of its diagnostic criteria, as well as the paucity of literature available. Antibiotics remain the first-line treatment option for SIBO, although emerging modalities such as probiotics and diet manipulation could also have a role. Herein, we present a state-of-the-art-review which aims to comprehensively outline the most current information on SIBO in children, with particular emphasis on the gut microbiota. | en |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Published Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.articleid | 363 | en |
| dc.identifier.citation | Avelar Rodriguez, D., Ryan, P. M., Toro Monjaraz, E. M., Ramirez Mayans, J. A. and Quigley, E. M. (2019) 'Small Intestinal Bacterial Overgrowth in Children: A State-Of-The-Art Review', Frontiers in Pediatrics, 7, 363 (20pp). DOI: 10.3389/fped.2019.00363 | en |
| dc.identifier.doi | 10.3389/fped.2019.00363 | en |
| dc.identifier.eissn | 2296-2360 | |
| dc.identifier.endpage | 20 | en |
| dc.identifier.journaltitle | Frontiers in Pediatrics | en |
| dc.identifier.startpage | 1 | en |
| dc.identifier.uri | https://hdl.handle.net/10468/8712 | |
| dc.identifier.volume | 7 | en |
| dc.language.iso | en | en |
| dc.publisher | Frontiers Media | en |
| dc.relation.uri | https://www.frontiersin.org/articles/10.3389/fped.2019.00363/full | |
| dc.rights | ©2019 Avelar Rodriguez, Ryan, Toro Monjaraz, Ramirez Mayans and Quigley. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | Small intestine bacterial overgrowth | en |
| dc.subject | Small bowel bacterial overgrowth | en |
| dc.subject | Proton pump inhibitors | en |
| dc.subject | Gut microbiota | en |
| dc.subject | Stunting | en |
| dc.title | Small intestinal bacterial overgrowth in children: A state-of-the-art review | en |
| dc.type | Article (peer-reviewed) | en |
