Recurrent asthma exacerbations: Co-existing asthma and common variable immunodeficiency

dc.check.date2022-05-08
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorIbrahim, H.
dc.contributor.authorWalsh, J.
dc.contributor.authorCasey, D.
dc.contributor.authorMurphy, J.
dc.contributor.authorPlant, Barry J.
dc.contributor.authorO'Leary, Paula
dc.contributor.authorMurphy, Desmond M.
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2021-05-11T11:30:57Z
dc.date.available2021-05-11T11:30:57Z
dc.date.issued2021-05-08
dc.date.updated2021-05-07T08:44:42Z
dc.description.abstractIntroduction: Common variable immunodeficiency is characterized by impaired B-cell differentiation and defective immunoglobulin production manifesting as recurrent respiratory tract infections. While the condition can masquerade as asthma, late diagnosis of CVID in known asthmatic is rarely reported. Case Study: We present the case of a 43-year-old lady with recurrent episodes of wheeze, cough, sinusitis and multiple lower respiratory tract infections. Transiently responsive to antibiotics and steroids. These episodes had been occurring for many years and she had a longstanding clinical diagnosis of asthma. Results: As part of her work up for recurrent respiratory tract infections a CT thorax was performed and demonstrated bronchiectasis. Further tests including Immunoglobulin levels revealed critically low IgG, IgM, and IgA levels. Immunoglobulin replacement therapy was commenced with a reduction in exacerbation frequency and severity, and objective improvement of asthma control. Subsequent lung function tests demonstrated reversible airflow limitation (obstructive lung function with 13% reversibility in FEV1 post-bronchodilator) consistent with asthma. Conclusion: Our case illustrates the importance of searching for alternate and co-existent diagnoses in patients diagnosed with asthma who are unresponsive to conventional therapy. We believe that serum immunoglobulin measurement should form a component of such a workup.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationIbrahim, H., Walsh, J., Casey, D., Murphy, J., Plant, B. J., O'Leary, P. and Murphy, D. M. (2021) 'Recurrent asthma exacerbations: Co-existing asthma and common variable immunodeficiency', Journal of Asthma. doi: 10.1080/02770903.2021.1922913en
dc.identifier.doi10.1080/02770903.2021.1922913en
dc.identifier.eissn1532-4303
dc.identifier.issn0277-0903
dc.identifier.journaltitleJournal of Asthmaen
dc.identifier.urihttps://hdl.handle.net/10468/11280
dc.language.isoenen
dc.publisherTaylor & Francis Groupen
dc.rights© 2021, Taylor & Francis Group, LLC. This is an Accepted Manuscript of an item published by Taylor & Francis in Journal of Asthma on 8 May 2021, available online: https://doi.org/10.1080/02770903.2021.1922913en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectImmunodeficiencyen
dc.subjectAsthmaen
dc.subjectBronchiectasisen
dc.subjectImmunoglobulinsen
dc.subjectLower respiratory tract infectionsen
dc.subjectSpirometryen
dc.titleRecurrent asthma exacerbations: Co-existing asthma and common variable immunodeficiencyen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Recurrent_Asthma_Exacerbations_Co_existing_Asthma_and_Common_Variable_Immunodeficiency.pdf
Size:
617 KB
Format:
Adobe Portable Document Format
Description:
Accepted Version
License bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description: