Enhanced skin deposition and delivery of voriconazole using ethosomal preparations.

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dc.contributor.authorFaisal, Waleed
dc.contributor.authorSoliman, Ghareb M
dc.contributor.authorHamdan, Ahmed M
dc.date.accessioned2021-02-11T11:46:30Z
dc.date.available2021-02-11T11:46:30Z
dc.date.issued2016-09-25
dc.date.updated2021-02-09T11:53:36Z
dc.description.abstractDespite its broad-spectrum antifungal properties, voriconazole has many side effects when administered systemically. The aim of this work was to develop an ethosomal topical delivery system for voriconazole and test its potential to enhance the antifungal properties and skin delivery of the drug. Voriconazole was encapsulated into various ethosomal preparations and the effect of phospholipid and ethanol concentrations on the ethosomes properties were evaluated. The ethosomes were evaluated for drug encapsulation efficiency, particle size and morphology and antifungal efficacy. Drug permeability and deposition were tested in rat abdominal skin. Drug encapsulation efficiency of up to 46% was obtained and it increased with increasing the phospholipid concentration, whereas the opposite effect was observed for the ethanol concentration. The ethosomes had a size of 420–600 nm and negative zeta potential. The particle size of the ethosomes increased by increasing their ethanol content. The ethosomes achieved similar inhibition zones against Aspergillus flavus at a 2-fold lower drug concentration compared with drug solution in dimethyl sulfoxide. The ex vivo drug permeability through rat abdominal skin was ∼6-fold higher for the ethosomes compared with the drug hydroalcoholic solution. Similarly, the amount of drug deposited in the skin was higher for the ethosomes and was dependent on the ethanol concentration of the ethosomes. These results confirm that voriconazole ethosomal preparations are promising topical delivery systems that can enhance the drug antifungal efficacy and improve its skin delivery.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationFaisal, W., Soliman, G. M. and Hamdan, A. M. (2018) 'Enhanced skin deposition and delivery of voriconazole using ethosomal preparations', Journal of Liposome Research, 28(1), pp. 14-21. doi: 10.1080/08982104.2016.1239636en
dc.identifier.doi10.1080/08982104.2016.1239636en
dc.identifier.endpage21en
dc.identifier.issn1532-2394
dc.identifier.issued1en
dc.identifier.journaltitleJournal of Liposome Researchen
dc.identifier.startpage14en
dc.identifier.urihttps://hdl.handle.net/10468/11059
dc.identifier.volume28en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.urihttps://www.tandfonline.com/doi/full/10.1080/08982104.2016.1239636
dc.rights© 2016 Informa UK Ltd. Trading as Taylor & Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Liposome Research on 19 Oct 2016, available online: http://www.tandfonline.com/10.1080/08982104.2016.1239636en
dc.subjectAspergillus flavusen
dc.subjectEthosomesen
dc.subjectSkin permeabilityen
dc.subjectTopical deliveryen
dc.subjectVoriconazoleen
dc.titleEnhanced skin deposition and delivery of voriconazole using ethosomal preparations.en
dc.typeArticle (peer-reviewed)en
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