Aiming at the lung microbiota in adult asthma; an asthmatic immune microbe dialogue?

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dc.availability.bitstreamembargoed
dc.check.date2026-05-25
dc.contributor.advisorMacSharry, Johnen
dc.contributor.advisorMurphy, Desen
dc.contributor.authorSullivan, Ashley
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderIrish Lung Foundationen
dc.contributor.funderAPC Microbiome Instituteen
dc.contributor.funderUniversity College Corken
dc.contributor.funderEuropean Respiratory Societyen
dc.contributor.funderWilton Respiratory Research Funden
dc.date.accessioned2021-05-20T10:42:35Z
dc.date.available2021-05-20T10:42:35Z
dc.date.issued2020
dc.date.submitted2020
dc.description.abstractWithin this thesis we have reported novel findings which will contribute to a better understanding of the role the microbiota plays within the lungs of clinically diagnosed asthmatic patients. The prevalence of asthma is increasing in the western world with more than 300 million people worldwide believed to be affected by this chronic respiratory disorder. Through this thesis we have dissected the immune microbe dialogue at play within the asthmatic lung. The findings within this thesis are novel, and we feel add to recent discoveries within the field of microbiome research, with an emphasis on the potential contribution the lung microbiome may play in the pathogenesis of asthma.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMurphy, A. 2020. Aiming at the lung microbiota in adult asthma; an asthmatic immune microbe dialogue?. PhD Thesis, University College Cork.en
dc.identifier.endpage500en
dc.identifier.urihttps://hdl.handle.net/10468/11362
dc.language.isoenen
dc.publisherUniversity College Corken
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectAPC Microbiome Institute (Innovation Fund)en
dc.relation.projectUniversity College Cork (School of Medicine TRAP Award)en
dc.relation.projectEuropean Respiratory Society (Fellowship STRF-2018)en
dc.rights© 2020, Ashley Sullivan.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectAsthmaen
dc.subjectMicrobiomeen
dc.subjectImmunologyen
dc.subjectqPCRen
dc.subjectSequencingen
dc.subjectImmunoglobulinsen
dc.subjectMonoclonal antibody therapyen
dc.subjectPatient cohort studiesen
dc.subjectCell cultureen
dc.titleAiming at the lung microbiota in adult asthma; an asthmatic immune microbe dialogue?en
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD - Doctor of Philosophyen
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