Development of anisamide-targeted PEGylated gold nanorods to deliver epirubicin for chemo-photothermal therapy in tumour-bearing mice

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dc.contributor.authorWang, Limei
dc.contributor.authorPei, Jin
dc.contributor.authorCong, Zhongcheng
dc.contributor.authorZou, Yifang
dc.contributor.authorSun, Tianmeng
dc.contributor.authorDavitt, Fionán
dc.contributor.authorGarcia-Gil, Adrià
dc.contributor.authorHolmes, Justin D.
dc.contributor.authorO'Driscoll, Caitríona M.
dc.contributor.authorRahme, Kamil
dc.contributor.authorGuo, Jianfeng
dc.contributor.funderDepartment of Science and Technology of Jilin Provinceen
dc.contributor.funderJilin Universityen
dc.date.accessioned2019-04-05T10:12:31Z
dc.date.available2019-04-05T10:12:31Z
dc.date.issued2019-03-08
dc.date.updated2019-04-01T13:14:44Z
dc.description.abstractBackground: Gold nanorods (AuNRs), due to the optical and electronic properties namely the surface plasma resonance, have been developed to achieve the light-mediated photothermal therapy (PTT) for cancer. However, PTT alone may suffer from inefficient tumor killing. Recently, the combination of PTT and chemotherapy has been utilized to achieve synergistic anticancer effects. Methods: In this study, AuNRs capped with hexadecyltrimethylammonium bromide (CTAB), poly(acrylic acid) (PAA), and PEGylated anisamide (a ligand known to target the sigma receptor) have been developed to produce a range of negatively charged anisamide-targeted PEGylated AuNRs (namely Au-CTAB-PAA-PEG-AA) for the combination of PTT and chemotherapy (termed as chemo-photothermal therapy [CPTT]). Epirubicin (EPI, an anthracycline drug) was efficiently loaded onto the surface of Au800-CTAB-PAA-PEG-AA via the electrostatic interaction forming Au800-CTAB-PAA-PEG-AA.EPI complex. Results: The resultant complex demonstrated pH-dependent drug release, facilitated nucleus trafficking of EPI, and induced antiproliferative effects in human prostate cancer PC-3 cells. When Au800-CTAB-PAA-PEG-AA.EPI complex was further stimulated with desired laser irradiation, the synergistic outcome was evident in PC-3 xenograft mice. Conclusion: These results demonstrate a promising strategy for clinical application of CPTT in cancer.en
dc.description.sponsorshipDepartment of Science and Technology of Jilin Province, China (Outstanding Youth Foundation (20170520046JH)); Jilin University (Start-Up Research Grant Program (451170301168, 451160102052, 419080500667)); Central Universities, China (Fundamental Research Funds)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationWang, L., Pei, J., Cong, Z., Zou, Y., Sun, T., Davitt, F., Garcia-Gil, A., Holmes, J. D., O' Driscoll, C. M., Rahme, K. and Guo, J. (2019) 'Development of anisamide-targeted PEGylated gold nanorods to deliver epirubicin for chemo-photothermal therapy in tumour-bearing mice', International Journal of Nanomedicine, 14, pp. 1817-1833. doi: 10.2147/IJN.S192520en
dc.identifier.doi10.2147/IJN.S192520en
dc.identifier.eissn1178-2013
dc.identifier.endpage1833en
dc.identifier.issn1176-9114
dc.identifier.journaltitleInternational Journal of Nanomedicineen
dc.identifier.startpage1817en
dc.identifier.urihttps://hdl.handle.net/10468/7718
dc.identifier.volume14en
dc.language.isoenen
dc.publisherDove Pressen
dc.relation.urihttps://www.dovepress.com/development-of-anisamide-targeted-pegylated-gold-nanorods-to-deliver-e-peer-reviewed-article-IJN
dc.rights© 2019 Wang et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php)en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en
dc.subjectGold nanoparticlesen
dc.subjectNon-viral drug deliveryen
dc.subjectChemotherapyen
dc.subjectPhotothermal therapyen
dc.subjectSynergistic effecten
dc.titleDevelopment of anisamide-targeted PEGylated gold nanorods to deliver epirubicin for chemo-photothermal therapy in tumour-bearing miceen
dc.typeArticle (peer-reviewed)en
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