dc.contributor.author	Alessandri, Giulia
dc.contributor.author	Milani, Christian
dc.contributor.author	Duranti, Sabrina
dc.contributor.author	Mancabelli, Leonardo
dc.contributor.author	Ranjanoro, Thibaut
dc.contributor.author	Modica, Salvatore
dc.contributor.author	Carnevali, Luca
dc.contributor.author	Statello, Rosario
dc.contributor.author	Bottacini, Francesca
dc.contributor.author	Turroni, Francesca
dc.contributor.author	Ossiprandi, Maria Cristina
dc.contributor.author	Sgoifo, Andrea
dc.contributor.author	van Sinderen, Douwe
dc.contributor.author	Ventura, Marco
dc.contributor.funder	KitoZyme, Belgium	en
dc.contributor.funder	University of Parma, Italy	en
dc.contributor.funder	GenProbio srl	en
dc.date.accessioned	2019-11-19T12:08:09Z
dc.date.available	2019-11-19T12:08:09Z
dc.date.issued	2019-04-08
dc.description.abstract	Chitin-glucan (CG) represents a natural carbohydrate source for certain microbial inhabitants of the human gut and may act as a prebiotic for a number of bacterial taxa. However, the bifidogenic activity of this substrate is still unknown. In the current study, we evaluated the ability of chitin-glucan to influence growth of 100 bifidobacterial strains belonging to those species commonly identified within the bifidobacterial communities residing in the infant and adult human gut. Such analyses were coupled with transcriptome experiments directed to explore the transcriptional effects of CG on Bifidobacterium breve 2L, which was shown to elicit the highest growth performance on this natural polysaccharide. In addition, an in vivo trial involving a rat model revealed how the colonization efficiency of this bifidobacterial strain was enhanced when the animals were fed with a diet containing CG. Altogether our analyses indicate that CG is a valuable novel prebiotic compound that may be added to the human diet in order to re-establish/reinforce bifidobacteria colonization in the mammalian gut.	en
dc.description.sponsorship	ADIPOSTOP project	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.articleid	5755	en
dc.identifier.citation	Alessandri, G., Milani, C., Duranti, S., Mancabelli, L., Ranjanoro, T., Modica, S., Carnevali, L., Statello, R., Bottacini, F., Turroni, F. and Ossiprandi, M.C., 2019. Ability of bifidobacteria to metabolize chitin-glucan and its impact on the gut microbiota. Scientific reports, 9(1), (5755). DOI:10.1038/s41598-019-42257-z	en
dc.identifier.doi	10.1038/s41598-019-42257-z	en
dc.identifier.eissn	2045-2322
dc.identifier.endpage	14	en
dc.identifier.issued	1	en
dc.identifier.journaltitle	Scientific Reports	en
dc.identifier.startpage	1	en
dc.identifier.uri	https://hdl.handle.net/10468/9085
dc.identifier.volume	9	en
dc.language.iso	en	en
dc.publisher	Nature Publishing Group	en
dc.relation.uri	https://www.nature.com/articles/s41598-019-42257-z
dc.rights	© The Author(s) 2019	en
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	en
dc.subject	Chitin-glucan (CG)	en
dc.subject	Bifidobacteria	en
dc.subject	Gut microbiota	en
dc.title	Ability of bifidobacteria to metabolize chitin-glucan and its impact on the gut microbiota	en
dc.type	Article (peer-reviewed)	en

Ability of bifidobacteria to metabolize chitin-glucan and its impact on the gut microbiota

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