Structural model of a bacterial focal adhesion complex

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dc.contributor.authorCambillau, Christianen
dc.contributor.authorMignot, Tâmen
dc.contributor.funderGrand Equipement National de Calcul Intensifen
dc.contributor.funderEuropean Research Councilen
dc.date.accessioned2025-04-23T11:14:58Z
dc.date.available2025-04-23T11:14:58Z
dc.date.issued2025en
dc.description.abstractCell movement on surfaces relies on focal adhesion complexes (FAs), which connect cytoskeletal motors to the extracellular matrix to produce traction forces. The soil bacterium Myxococcus xanthus uses a bacterial FA (bFA), for surface movement and predation. The bFA system, known as Agl-Glt, is a complex network of at least 17 proteins spanning the cell envelope. Despite understanding the system dynamics, its molecular structure and protein interactions remain unclear. In this study, we utilize AlphaFold to generate models based on the known interactions and dynamics of gliding motility proteins. This approach provides us with a comprehensive view of the interactions across the entire complex. Our structural insights show the connection of essential functional modules throughout the cell envelope and offer an inspiring view of the force transduction mechanism from the inner molecular motor to the exterior of the cell. © The Author(s) 2025.en
dc.description.sponsorshipEuropean Research Council (885145)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid119en
dc.identifier.citationCambillau, C. and Mignot, T. (2025) 'Structural model of a bacterial focal adhesion complex', Communications Biology, 8(1), p.119. https://doi.org/10.1038/s42003-025-07550-wen
dc.identifier.doi10.1038/s42003-025-07550-wen
dc.identifier.issn23993642en
dc.identifier.issued1
dc.identifier.journaltitleCommunications Biologyen
dc.identifier.urihttps://hdl.handle.net/10468/17297
dc.identifier.volume8
dc.language.isoenen
dc.publisherNature Researchen
dc.relation.project885145en
dc.rights© 2025, the Author(s). Open Accessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBacterial proteinsen
dc.subjectFocal adhesionsen
dc.subjectModels, molecularen
dc.subjectMyxococcus xanthusen
dc.subjectBacterial proteinen
dc.subjectChemistryen
dc.titleStructural model of a bacterial focal adhesion complexen
dc.typeArticle (peer reviewed)en
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