Exploiting the continuous in situ generation of mesyl azide for use in a telescoped process

dc.contributor.authorO'Mahony, Rosella M.
dc.contributor.authorLynch, Denis
dc.contributor.authorHayes, Hannah L. D.
dc.contributor.authorNí Thuama, Eilís
dc.contributor.authorDonnellan, Philip
dc.contributor.authorJones, Roderick C.
dc.contributor.authorGlennon, Brian
dc.contributor.authorCollins, Stuart G.
dc.contributor.authorMaguire, Anita R.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2020-11-18T11:01:59Z
dc.date.available2020-11-18T11:01:59Z
dc.date.issued2017-08-21
dc.date.updated2020-11-18T10:52:21Z
dc.description.abstractThe hazardous diazo transfer reagent mesyl azide has been safely generated and used in situ for continuous diazo transfer as part of an integrated synthetic process with an embedded safety quench. Diazo transfer to β‐keto esters and a β‐ketosulfone was successful. In‐line phase separation, by means of a continuous liquid–liquid separator enabled direct telescoping with a thermal Wolff rearrangement. 12en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Mahony, R. M., Lynch, D., Hayes, H. L. D., Ní Thuama, E., Donnellan, P., Jones, R. C., Glennon, B., Collins, S. G. and Maguire, A. R. (2017) 'Exploiting the Continuous in situ Generation of Mesyl Azide for Use in a Telescoped Process', European Journal of Organic Chemistry, 2017(44), pp. 6533-6539. doi: 10.1002/ejoc.201700871en
dc.identifier.doi10.1002/ejoc.201700871en
dc.identifier.endpage6539en
dc.identifier.issn1434-193X
dc.identifier.issued44en
dc.identifier.journaltitleEuropean Journal of Organic Chemistryen
dc.identifier.startpage6533en
dc.identifier.urihttps://hdl.handle.net/10468/10769
dc.language.isoenen
dc.publisherWileyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Infrastructure Programme/15/RI/3221/IE/Process Flow Spectroscopy (ProSpect); Advanced Reaction Understanding using Flow Nuclear Magnetic Resonance (NMR) and Infrared (IR) Spectroscopies, with On-Line Ultra-Performance Liquid Chromatography (UPLC) and Mass Spectrometry (MS)/en
dc.relation.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.201700871
dc.rights© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: O'Mahony, R.M. et al. (2017), Exploiting the Continuous in situ Generation of Mesyl Azide for Use in a Telescoped Process. Eur. J. Org. Chem., 2017, which has been published in final form at https://doi.org/10.1002/ejoc.201700871 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en
dc.subjectContinuous flowen
dc.subjectDiazo compoundsen
dc.subjectFlowen
dc.subjectChemistryen
dc.subjectSynthetic methodsen
dc.titleExploiting the continuous in situ generation of mesyl azide for use in a telescoped processen
dc.typeArticle (peer-reviewed)en
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