dc.contributor.author	Masukume, Gwinyai
dc.contributor.author	Khashan, Ali S.
dc.contributor.author	Morton, Susan M. B.
dc.contributor.author	Baker, Philip N.
dc.contributor.author	Kenny, Louise C.
dc.contributor.author	McCarthy, Fergus P.
dc.contributor.funder	Science Foundation Ireland	en
dc.date.accessioned	2019-12-04T10:54:16Z
dc.date.available	2019-12-04T10:54:16Z
dc.date.issued	2019-10-30
dc.description.abstract	Background: Several studies reported an association between Caesarean section (CS) birth and childhood obesity. However, there are several limitations in the current literature. These include an inability to distinguish between planned and emergency CS, small study sample sizes and not adjusting for pre-pregnancy body-mass-index (BMI). We examined the association between CS delivery and childhood obesity using the United Kingdom Millennium Cohort Study (MCS). Methods: Mother-infant pairs were recruited into the MCS. Use of sampling weights ensured the sample was representative of the population. The exposure was categorised as normal vaginal delivery (VD) [reference], assisted VD, planned CS and emergency CS. Childhood obesity prevalence, at age three, five, seven, eleven and fourteen years was calculated using the International Obesity Taskforce criteria. Mixed-effects linear regression models were fitted with associations adjusted for several potential confounders like maternal age, pre-pregnancy BMI, education and infant macrosomia. Linear regression models were fitted evaluating body fat percentage (BF%), at age seven and fourteen years. Results: Of the 18,116 infants, 3872 (21.4%) were delivered by CS; 9.2% by planned CS. Obesity prevalence was 5.4%, 5.7%, 6.5%, 7.1% and 7.6% at age three, five, seven, eleven and fourteen years respectively. The mixed-effects linear regression model showed no association between planned (adjusted mean difference = 0.00; [95% confidence interval (CI) -0.10; 0.10], p-value = 0.97) or emergency CS (adjusted mean difference = 0.08; [95% CI -0.01; 0.17], p-value = 0.09) and child BMI. At age seven years, there was no association between planned CS and BF% (adjusted mean difference = 0.13; [95% CI -0.23; 0.49]); there was no association at age fourteen years. Conclusions: Infants born by planned CS did not have a significantly higher BMI or BF% compared to those born by normal VD. This may suggest that the association, described in the literature, could be due to the indications/reasons for CS birth or residual confounding.	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.articleid	e0223856	en
dc.identifier.citation	Masukume, G., Khashan, A. S., Morton, S. M. B., Baker, P. N., Kenny, L. C. and McCarthy, F. P. (2019) 'Caesarean section delivery and childhood obesity in a British longitudinal cohort study', PLOS ONE, 14(10), e0223856. (13pp.) doi: 10.1371/journal.pone.0223856	en
dc.identifier.doi	10.1371/journal.pone.0223856	en
dc.identifier.eissn	1932-6203
dc.identifier.endpage	13	en
dc.identifier.issued	10	en
dc.identifier.journaltitle	PLOS ONE	en
dc.identifier.startpage	1	en
dc.identifier.uri	https://hdl.handle.net/10468/9315
dc.identifier.volume	13	en
dc.language.iso	en	en
dc.publisher	Public Library of Science	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/	en
dc.rights	©2019 Masukume et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.	en
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	en
dc.subject	Caesarean section (CS)	en
dc.subject	Childhood obesity	en
dc.subject	Britain	en
dc.title	Caesarean section delivery and childhood obesity in a British longitudinal cohort study	en
dc.type	Article (peer-reviewed)	en

Caesarean section delivery and childhood obesity in a British longitudinal cohort study

Files

Original bundle

License bundle

Collections