Emerging issues in probiotic safety: 2023 perspectives

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dc.contributor.authorMerenstein, Danielen
dc.contributor.authorPot, Brunoen
dc.contributor.authorLeyer, Gregoryen
dc.contributor.authorOuwehand, Arthur C.en
dc.contributor.authorPreidis, Geoffrey A.en
dc.contributor.authorElkins, Christopher A.en
dc.contributor.authorHill, Colinen
dc.contributor.authorLewis, Zachery T.en
dc.contributor.authorShane, Andi L.en
dc.contributor.authorZmora, Niven
dc.contributor.authorPetrova, Mariya I.en
dc.contributor.authorCollado, Maria Carmenen
dc.contributor.authorMorelli, Lorenzoen
dc.contributor.authorMontoya, Gina A.en
dc.contributor.authorSzajewska, Haniaen
dc.contributor.authorTancredi, Daniel J.en
dc.contributor.authorSanders, Mary Ellenen
dc.date.accessioned2024-04-18T14:31:05Z
dc.date.available2024-04-18T14:31:05Z
dc.date.issued2023en
dc.description.abstractProbiotics are used for both generally healthy consumers and in clinical settings. However, theoretical and proven adverse events from probiotic consumption exist. New probiotic strains and products, as well as expanding use of probiotics into vulnerable populations, warrants concise, and actionable recommendations on how to work toward their safe and effective use. The International Scientific Association for Probiotics and Prebiotics convened a meeting to discuss and produce evidence-based recommendations on potential acute and long-term risks, risks to vulnerable populations, the importance for probiotic product quality to match the needs of vulnerable populations, and the need for adverse event reporting related to probiotic use. The importance of whole genome sequencing, which enables determination of virulence, toxin, and antibiotic resistance genes, as well as clear assignment of species and strain identity, is emphasized. We present recommendations to guide the scientific and medical community on judging probiotic safety.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMerenstein, D., Pot, B., Leyer, G., Ouwehand, A.C., Preidis, G.A., Elkins, C.A., Hill, C., Lewis, Z.T., Shane, A.L., Zmora, N., Petrova, M.I., Collado, M.C., Morelli, L., Montoya, G.A., Szajewska, H., Tancredi, D.J. and Sanders, M.E. (2023) ‘Emerging issues in probiotic safety: 2023 perspectives’, Gut Microbes, 15(1), 2185034 (22pp). doi: 10.1080/19490976.2023.2185034en
dc.identifier.doi10.1080/19490976.2023.2185034en
dc.identifier.eissn1949-0984en
dc.identifier.endpage22en
dc.identifier.issn1949-0976en
dc.identifier.issued1en
dc.identifier.journaltitleGut Microbesen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15814
dc.identifier.volume15en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.rights© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectProbioticen
dc.subjectSafetyen
dc.subjectNext-generation probioticsen
dc.subjectAntibiotic resistanceen
dc.subjectMicrobiomeen
dc.subjectMicrobiotaen
dc.subjectGenome sequencingen
dc.subjectLive biotherapeutic productsen
dc.subjectInternational Scientific Association for Probiotics and Prebioticsen
dc.subjectISAPPen
dc.titleEmerging issues in probiotic safety: 2023 perspectivesen
dc.typeArticle (peer-reviewed)en
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