Microbial regulation of microRNA expression in the brain-gut axis

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dc.contributor.authorMoloney, Gerard M.
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorClarke, Gerard
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderAir Force Office of Scientific Researchen
dc.date.accessioned2019-10-11T08:29:48Z
dc.date.available2019-10-11T08:29:48Z
dc.date.issued2019-10-04
dc.date.updated2019-10-11T08:19:31Z
dc.description.abstractThe gut microbiome facilitates a consistent transfer of information between the gut and the brain and microRNAs may now represent a key signalling molecule that facilitates this relationship. This review will firstly examine how these small non-coding RNAs influence the gut microbiome, and secondly how the microbiome, when disturbed, may influence miRNA expression in the brain. In addition, we will examine the consequence that microbiome-related changes in miRNA expression have on neurodevelopment, behaviour and cognition. We will also discuss novel data that suggests miRNAs contained in our diet may influence our immune system in a positive manner, offering a further potential pathway for treatment of disorders of the gutâ brain axis that are influenced by the microbiome.en
dc.description.sponsorshipHealth Research Board (Grant number ILP-POR-2017-013); Air Force Office of Scientific Research (Grant number FA9550-17-1-006)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMoloney, G. M., Dinan, T. G., Clarke, G. and Cryan, J. F. (2019) 'Microbial regulation of microRNA expression in the brain-gut axis', Current Opinion in Pharmacology, 48, pp. 120-126. doi: 10.1016/j.coph.2019.08.005en
dc.identifier.doi10.1016/j.coph.2019.08.005en
dc.identifier.eissn1471-4973
dc.identifier.endpage126en
dc.identifier.issn1471-4892
dc.identifier.journaltitleCurrent Opinion In Pharmacologyen
dc.identifier.startpage120en
dc.identifier.urihttps://hdl.handle.net/10468/8739
dc.identifier.volume48en
dc.language.isoenen
dc.publisherElsevier Ltd.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S1471489219300748
dc.rights© 2019, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 licence.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectMicroRNAen
dc.subjectGut microbiomeen
dc.subjectMiRNAen
dc.subjectNeurodevelopmenten
dc.subjectBehaviouren
dc.subjectCognitionen
dc.subjectDieten
dc.subjectImmune systemen
dc.titleMicrobial regulation of microRNA expression in the brain-gut axisen
dc.typeArticle (peer-reviewed)en
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