Phages & antibiotic resistance: are the most abundant entities on earth ready for a comeback?

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dc.contributor.authorHill, Colin
dc.contributor.authorMills, Susan
dc.contributor.authorRoss, R. Paul
dc.date.accessioned2018-09-20T15:53:46Z
dc.date.available2018-09-20T15:53:46Z
dc.date.issued2018
dc.description.abstractBacteriophages, which lost out to antibiotic therapy in the past, may be poised to make a comeback. Once discarded because of their narrow activity spectrum, it can now be viewed as a major advantage that these intracellular, self-replicating entities can exert their killing effect with minimal damage to the commensal microbiome. In eastern Europe, phages continue to be used both prophylactically and therapeutically to treat infections. More recently, much needed regulated clinical trials are underway with a view to restoring phage therapy as a tool for mainstream medicine, although current regulations may impede their full potential. One hundred years after their discovery, and amid an antibiotic resistance crisis, we must ask, what can be done to harness their full antibacterial potential?en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHill, C., Mills, S. and Ross, R. P. (2018) 'Phages & antibiotic resistance: are the most abundant entities on earth ready for a comeback?', Future Microbiology, 13(6), pp. 711-726. doi: 10.2217/fmb-2017-0261en
dc.identifier.doi10.2217/fmb-2017-0261
dc.identifier.endpage726
dc.identifier.issn1746-0913
dc.identifier.issued6
dc.identifier.journaltitleFuture Microbiologyen
dc.identifier.startpage711
dc.identifier.urihttps://hdl.handle.net/10468/6845
dc.identifier.volume13
dc.language.isoenen
dc.publisherFuture Medicine Ltden
dc.relation.urihttps://www.futuremedicine.com/doi/10.2217/fmb-2017-0261
dc.rights© 2018, Future Medicine Ltd. This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAntibiotic resistanceen
dc.subjectBacteriophageen
dc.subjectClinical trialsen
dc.subjectEscherichia colien
dc.subjectPhage resistanceen
dc.subjectPseudomonas aeruginosaen
dc.subjectStaphylococcus aureusen
dc.titlePhages & antibiotic resistance: are the most abundant entities on earth ready for a comeback?en
dc.typeReviewen
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