Vitamin D intake, serum 25-hydroxyvitamin D status and response to moderate vitamin D3 supplementation: a randomised controlled trial in East African and Finnish women

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dc.contributor.authorAdebayo, Folasade A.
dc.contributor.authorItkonen, Suvi T.
dc.contributor.authorÖhman, Taina
dc.contributor.authorSkaffari, Essi
dc.contributor.authorSaarnio, Elisa M.
dc.contributor.authorErkkola, Maijaliisa
dc.contributor.authorCashman, Kevin D.
dc.contributor.authorLamberg-Allardt, Christel
dc.contributor.funderSeventh Framework Programmeen
dc.date.accessioned2018-03-15T09:53:23Z
dc.date.available2018-03-15T09:53:23Z
dc.date.issued2018-03-02
dc.date.updated2018-03-14T15:06:18Z
dc.description.abstractInsufficient vitamin D status (serum 25-hydroxyvitamin D (S-25(OH)D)<50 nmol/l) is common among immigrants living at the northern latitudes. We investigated ethnic differences in response of S-25(OH)D to vitamin D3 supplementation, through a 5-month randomised controlled trial, in East African and Finnish women in Southern Finland (60°N) from December 2014 to May 2015. Vitamin D intakes (dietary and supplemental) were also examined. Altogether, 191 subjects were screened and 147 women (East Africans n 72, Finns n 75) aged 21–64 years were randomised to receive placebo or 10 or 20 µg of vitamin D3/d. S-25(OH)D concentrations were assessed by liquid chromatography–tandem MS. At screening, 56 % of East Africans and 9 % of Finns had S-25(OH)D<50 nmol/l. Total vitamin D intake was higher in East Africans than in Finns (24·2 (sd 14·3) v. 15·2 (sd 13·4) µg/d, P<0·001). Baseline mean S-25(OH)D concentrations were higher in Finns (60·5 (sd=16·3) nmol/l) than in East Africans (51·5 (sd 15·4) nmol/l) (P=0·001). In repeated-measures ANCOVA (adjusted for baseline S-25(OH)D), mean S-25(OH)D increased by 8·5 and 10·0 nmol/l with a 10-µg dose and by 10·7 and 17·1 nmol/l with a 20-µg dose for Finns and East Africans, respectively (P>0·05 for differences between ethnic groups). In conclusion, high prevalence of vitamin D insufficiency existed among East African women living in Finland, despite higher vitamin D intake than their Finnish peers. Moderate vitamin D3 supplementation was effective in increasing S-25(OH)D in both groups of women, and no ethnic differences existed in the response to supplementation.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAdebayo, F. A., Itkonen, S. T., Öhman, T., Skaffari, E., Saarnio, E. M., Erkkola, M., Cashman, K. D. and Lamberg-Allardt, C. (2018) 'Vitamin D intake, serum 25-hydroxyvitamin D status and response to moderate vitamin D3 supplementation: a randomised controlled trial in East African and Finnish women', British Journal of Nutrition, 119(4), pp. 431-441. doi:10.1017/S000711451700397Xen
dc.identifier.doi10.1017/S000711451700397X
dc.identifier.endpage441en
dc.identifier.issn0007-1145
dc.identifier.issued4en
dc.identifier.journaltitleBritish Journal of Nutritionen
dc.identifier.startpage431en
dc.identifier.urihttps://hdl.handle.net/10468/5623
dc.identifier.volume119en
dc.language.isoenen
dc.publisherCambridge University Press (CUP)en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613977/EU/Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle/ODINen
dc.rights© The Authors 2018en
dc.subjectVitamin Den
dc.subjectVitamin D3en
dc.subject25-Hydroxyvitamin Den
dc.subjectRandomised controlled trialsen
dc.subjectSupplementationen
dc.titleVitamin D intake, serum 25-hydroxyvitamin D status and response to moderate vitamin D3 supplementation: a randomised controlled trial in East African and Finnish womenen
dc.typeArticle (peer-reviewed)en
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