Dual wavelengths inverse spatially offset Raman spectroscopy for bone characterization

Simple item page
dc.contributor.authorMa, Huien
dc.contributor.authorGautam, Rekhaen
dc.contributor.authorKonugolu Venkata Sekar, Sanathanaen
dc.contributor.authorO'Flynn, Carrieen
dc.contributor.authorHenn, Patricken
dc.contributor.authorAndersson-Engels, Stefanen
dc.contributor.editorBoudoux, Carolineen
dc.contributor.editorTunnell, James W.en
dc.date.accessioned2023-05-02T14:32:07Z
dc.date.available2023-05-02T14:32:07Z
dc.date.issued2023-03-06en
dc.description.abstractOsteoporosis is a disease that weakens bones increasing the possibility of bone fracture. The gold standard to diagnose osteoporosis is measuring bone mineral density (BMD). Since BMD only partly determines the strength of the bone, more information on chemical composition and microstructure is needed. Here, we implemented a novel dual-wavelength inverse Spatially Offset Raman Spectroscopy (SORS) to characterize tissue chemical composition covering both the fingerprint and high-wavenumber regions. This system provides a greater probing depth keeping the spectrometer setting constant. The results from hydroxyapatite (HA) and water phantom demonstrate the potential of the Raman system to assess bone mineral and matrix quality in-vivo.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid123680Aen
dc.identifier.citationMa, H., Gautam, R., Konugolu Venkata Sekar, S., O'Flynn, C., Henn, P. and Andersson-Engels, S. (2023) 'Dual wavelengths inverse spatially offset Raman spectroscopy for bone characterization', Proceedings of SPIE, 12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI, 123680A (4pp). doi: 10.1117/12.2650089en
dc.identifier.doi10.1117/12.2650089en
dc.identifier.eissn1996-756Xen
dc.identifier.endpage4en
dc.identifier.issn0277-786Xen
dc.identifier.journaltitleProceedings of SPIEen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/14422
dc.identifier.volume12368en
dc.language.isoenen
dc.publisherSociety of Photo-Optical Instrumentation Engineers (SPIE)en
dc.relation.ispartofProceedings Volume 12368 SPIE BIOS, 28 January - 3 February 2023: Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXIen
dc.rights© 2023, Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.en
dc.subjectOsteoporosisen
dc.subjectRamanen
dc.subjectSORSen
dc.subjectBMDen
dc.subjectHydrationen
dc.titleDual wavelengths inverse spatially offset Raman spectroscopy for bone characterizationen
dc.typeConference itemen
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
123680A.pdf
Size:
459.08 KB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Tyndall National Institute - Conference Items
ASSERT - Conference Items
Physics - Conference Items