Dual wavelengths inverse spatially offset Raman spectroscopy for bone characterization

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2023-03-06
Authors
Ma, Hui
Gautam, Rekha
Konugolu Venkata Sekar, Sanathana
O'Flynn, Carrie
Henn, Patrick
Andersson-Engels, Stefan
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Society of Photo-Optical Instrumentation Engineers (SPIE)
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Abstract
Osteoporosis is a disease that weakens bones increasing the possibility of bone fracture. The gold standard to diagnose osteoporosis is measuring bone mineral density (BMD). Since BMD only partly determines the strength of the bone, more information on chemical composition and microstructure is needed. Here, we implemented a novel dual-wavelength inverse Spatially Offset Raman Spectroscopy (SORS) to characterize tissue chemical composition covering both the fingerprint and high-wavenumber regions. This system provides a greater probing depth keeping the spectrometer setting constant. The results from hydroxyapatite (HA) and water phantom demonstrate the potential of the Raman system to assess bone mineral and matrix quality in-vivo.
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Osteoporosis , Raman , SORS , BMD , Hydration
Citation
Ma, H., Gautam, R., Konugolu Venkata Sekar, S., O'Flynn, C., Henn, P. and Andersson-Engels, S. (2023) 'Dual wavelengths inverse spatially offset Raman spectroscopy for bone characterization', Proceedings of SPIE, 12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI, 123680A (4pp). doi: 10.1117/12.2650089
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© 2023, Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.