Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort

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dc.contributor.authorKenny, Louise C.
dc.contributor.authorLavender, Tina
dc.contributor.authorMcNamee, Roseanne
dc.contributor.authorO'Neill, Sinéad M.
dc.contributor.authorMills, Tracey
dc.contributor.authorKhashan, Ali S.
dc.date.accessioned2016-02-17T11:46:20Z
dc.date.available2016-02-17T11:46:20Z
dc.date.issued2013
dc.description.abstractBackground: Recent decades have witnessed an increase in mean maternal age at childbirth in most high-resourced countries. Advanced maternal age has been associated with several adverse maternal and perinatal outcomes. Although there are many studies on this topic, data from large contemporary population-based cohorts that controls for demographic variables known to influence perinatal outcomes is limited. Methods: We performed a population-based cohort study using data on all singleton births in 2004-2008 from the North Western Perinatal Survey based at The University of Manchester, UK. We compared pregnancy outcomes in women aged 30-34, 35-39 and >= 40 years with women aged 20-29 years using log-linear binomial regression. Models were adjusted for parity, ethnicity, social deprivation score and body mass index. Results: The final study cohort consisted of 215,344 births; 122,307 mothers (54.19%) were aged 20-29 years, 62,371(27.63%) were aged 30-34 years, 33,966(15.05%) were aged 35-39 years and 7,066(3.13%) were aged >= 40 years. Women aged 40+ at delivery were at increased risk of stillbirth (RR = 1.83, [95% CI 1.37-2.43]), pre-term (RR = 1.25, [95% CI: 1.14-1.36]) and very pre-term birth (RR = 1.29, [95% CI: 1.08-1.55]), Macrosomia (RR = 1.31, [95% CI: 1.12-1.54]), extremely large for gestational age (RR = 1.40, [95% CI: 1.25-1.58]) and Caesarean delivery (RR = 1.83, [95% CI: 1.77-1.90]). Conclusions: Advanced maternal age is associated with a range of adverse pregnancy outcomes. These risks are independent of parity and remain after adjusting for the ameliorating effects of higher socioeconomic status. The data from this large contemporary cohort will be of interest to healthcare providers and women and will facilitate evidence based counselling of older expectant mothers.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide56583
dc.identifier.citationKenny LC, Lavender T, McNamee R, O’Neill SM, Mills T, Khashan AS (2013) Advanced Maternal Age and Adverse Pregnancy Outcome: Evidence from a Large Contemporary Cohort. PLoS ONE 8(2): e56583. doi:10.1371/journal.pone.0056583en
dc.identifier.doi10.1371/journal.pone.0056583
dc.identifier.issn1932-6203
dc.identifier.issued2en
dc.identifier.journaltitlePLOS ONEen
dc.identifier.urihttps://hdl.handle.net/10468/2392
dc.identifier.volume8en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rights© 2013 Kenny et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectCesarean section ratesen
dc.subjectDelayed childbearingen
dc.subjectFetal deathen
dc.subjectStillbirthen
dc.subjectRisken
dc.subjectPopulationen
dc.subjectWomenen
dc.subjectImpacten
dc.subjectOlderen
dc.titleAdvanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohorten
dc.typeArticle (peer-reviewed)en
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