Predicting surfactant effects on drug permeation across hollow fiber membrane

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dc.contributor.authorPatel, Roshni P.
dc.contributor.authorMurray, Jack D.
dc.contributor.authorGriffin, Brendan T.
dc.contributor.authorPolli, James E.
dc.contributor.funderU.S. Food and Drug Administration, FDA, U01FD005946
dc.contributor.funderU.S. Department of Health and Human Services, HHM, U01FD005946
dc.date.accessioned2026-10-19T15:50:01Z
dc.date.available2026-10-19T15:50:01Z
dc.date.issued2026-05-15
dc.description.abstractThe hollow fiber membrane (HFM) system is a potential combined dissolution/permeation in vitro tool to predict oral solid dosage form performance. However, drug permeability interpretation in the presence of surfactants remains mechanistically challenging, particularly when surfactants are present in both the donor and receiver compartments. A model denoted the reduced resistance model was recently employed to explain enhanced drug permeability when surfactant was present in the receiver. The objective was to re-examine previously published HFM flux of griseofulvin and meloxicam to consider the reduced resistance model as an additional contributing mechanism impacting drug flux. Published HFM data under all four surfactant experimental scenarios (i.e., no surfactant, surfactant in the receiver only, surfactant in the donor only, and surfactant in both donor and receiver) were re-analyzed. For the latter two most complex scenarios, there were six competing permeation models. For these two scenarios, the best predictive model for griseofulvin was the reduced resistance model for total donor drug concentration; meanwhile, for meloxicam, which was much less micelle incorporated, the best predictive model was the simple free drug permeation model. Overall, these findings demonstrate that drug permeation across HFM in surfactant-containing systems is governed by the interplay between donor-side micellar sequestration and receiver-side resistance reduction.en
dc.description.sponsorshipFood and Drug Administration (FDA)|U01FD005946
dc.description.sponsorshipU.S. Department of Health and Human Services (HHS)|U01FD005946
dc.description.versionPublished Version
dc.format.extent9
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid104318
dc.identifier.authororcidPatel, Roshni P.
dc.identifier.authororcidMurray, Jack D.§0000-0002-8168-1586
dc.identifier.authororcidGriffin, Brendan T.§0000-0001-5433-8398
dc.identifier.authororcidPolli, James E.
dc.identifier.citationPatel, R P, Murray, J D, Griffin, B T & Polli, J E 2026, 'Predicting surfactant effects on drug permeation across hollow fiber membrane', Journal of Pharmaceutical Sciences, vol. 115, no. 8, 104318, pp. 1-9. https://doi.org/10.1016/j.xphs.2026.104318
dc.identifier.doi10.1016/j.xphs.2026.104318
dc.identifier.endpage9
dc.identifier.issn0022-3549
dc.identifier.issued8
dc.identifier.journaltitleJournal of Pharmaceutical Sciences
dc.identifier.otherORCID: /0000-0002-8168-1586/work/213869260
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/19462
dc.identifier.volume115
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.urihttps://www.scopus.com/pages/publications/105038736794
dc.rights© 2026, authors. Published by Elsevier Inc. on behalf of American Pharmacists Association®. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.rights.accessrightsopen access
dc.rights.licensenameAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.statusPeer reviewed
dc.subjectFlux
dc.subjectFree drug
dc.subjectMembrane
dc.subjectModeling
dc.subjectPermeability
dc.subjectSurfactant
dc.subject[Pharmacy]
dc.titlePredicting surfactant effects on drug permeation across hollow fiber membraneen
dc.typeArticle (peer-reviewed)
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