Timed degradation of Mcl-1 controls mitotic cell death

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dc.contributor.authorClarke, Paul R.
dc.contributor.authorAllan, Lindsey A.
dc.contributor.authorSkowyra, Agnieszka
dc.contributor.funderCancer Research UKen
dc.contributor.funderAssociation for International Cancer Researchen
dc.date.accessioned2019-09-02T14:35:14Z
dc.date.available2019-09-02T14:35:14Z
dc.date.issued2018-10-11
dc.description.abstractMitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide1516450en
dc.identifier.citationClarke, P.R., Allan, L.A. and Skowyra, A., 2018. Timed degradation of Mcl-1 controls mitotic cell death. Molecular & cellular oncology, 5(6), (e1516450. DOI:10.1080/23723556.2018.1516450en
dc.identifier.doi10.1080/23723556.2018.1516450en
dc.identifier.eissn2372-3556
dc.identifier.endpage3en
dc.identifier.issued6en
dc.identifier.journaltitleMolecular and Cellular Oncologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8429
dc.identifier.volume5en
dc.language.isoenen
dc.publisherTaylor and Francis Ltd.en
dc.relation.urihttps://www.tandfonline.com/doi/full/10.1080/23723556.2018.1516450
dc.rights© 2018 The Author(s)en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectApoptosisen
dc.subjectMitosisen
dc.subjectMcl-1en
dc.subjectMitotic cell deathen
dc.subjectProteolysisen
dc.titleTimed degradation of Mcl-1 controls mitotic cell deathen
dc.typeArticle (peer-reviewed)en
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