Can EEG accurately predict 2-year neurodevelopmental outcome for preterm infants?

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dc.contributor.authorLloyd, Rhodri O.
dc.contributor.authorO'Toole, John M.
dc.contributor.authorLivingstone, Vicki
dc.contributor.authorFilan, Peter
dc.contributor.authorBoylan, Geraldine B.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2022-04-25T13:00:17Z
dc.date.available2022-04-25T13:00:17Z
dc.date.issued2021-09
dc.date.updated2022-04-22T15:09:24Z
dc.description.abstractObjective: Establish if serial multichannel video electroencephalography (EEG) in preterm infants can accurately predict 2-year neurodevelopmental outcome. Design and patients: EEGs were recorded at three time points over the neonatal course for infants <32 weeks’ gestational age (GA). Monitoring commenced soon after birth and continued over the first 3 days. EEGs were repeated at approximately 32 and 35 weeks’ postmenstrual age (PMA). EEG scores were based on an age- specific grading scheme. Clinical score of neonatal morbidity risk and cranial ultrasound imaging were completed. Setting: Neonatal intensive care unit at Cork University Maternity Hospital, Ireland. Main outcome measures: Bayley Scales of Infant Development III at 2 years’ corrected age. Results: Sixty- seven infants were prospectively enrolled in the study and 57 had follow- up available (median GA 28.9 weeks (IQR 26.5–30.4)). Forty had normal outcome, 17 had abnormal outcome/died. All EEG time points were individually predictive of abnormal outcome; however, the 35- week EEG performed best. The area under the receiver operating characteristic curve (AUC) for this time point was 0.91 (95% CI 0.83 to 1), p<0.001. Comparatively, the clinical course AUC was 0.68 (95% CI 0.54 to 0.80, p=0.015), while abnormal cranial ultrasound was 0.58 (95% CI 0.41 to 0.75, p=0.342). Conclusion: Multichannel EEG is a strong predictor of 2- year outcome in preterm infants particularly when recorded around 35 weeks’ PMA. Infants at high risk of brain injury may benefit from early postnatal EEG recording which, if normal, is reassuring. Postnatal clinical complications can contribute to poor outcome; therefore, we state that a later EEG around 35 weeks has a role to play in prognostication.en
dc.description.sponsorshipScience Foundation Ireland (Grant number 15/SIRG/3580)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLloyd, R. O., O'Toole, J. M. ,Livingstone, V., Filan, P. and Boylan, G. B. (2021) 'Can EEG accurately predict 2-year neurodevelopmental outcome for preterm infants?', Archives of Disease In Childhood-Fetal and Neonatal Edition, 106 (5), pp F535-F541. doi: 10.1136/archdischild-2020-319825en
dc.identifier.doi10.1136/archdischild-2020-319825en
dc.identifier.endpageF541en
dc.identifier.issn1359-2998
dc.identifier.issued5en
dc.identifier.journaltitleArchives of Disease In Childhood-Fetal and Neonatal Editionen
dc.identifier.startpageF535en
dc.identifier.urihttps://hdl.handle.net/10468/13114
dc.identifier.volume106en
dc.language.isoenen
dc.publisherBMJ Publishing Groupen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.rights© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.en
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectAmplitude-integrated EEGen
dc.subjectPremature-infantsen
dc.subjectBrain-injuryen
dc.subjectNeonatal EEGen
dc.subjectBayley-IIIen
dc.subjectElectroencephalographyen
dc.subjectSeverityen
dc.subjectChildrenen
dc.subjectSeizuresen
dc.subjectSepsisen
dc.titleCan EEG accurately predict 2-year neurodevelopmental outcome for preterm infants?en
dc.typeArticle (peer-reviewed)en
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