Biodiversity and classification of phages infecting Lactobacillus brevis

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dc.contributor.authorFeyereisen, Marine
dc.contributor.authorMahony, Jennifer
dc.contributor.authorNeve, Horst
dc.contributor.authorFranz, Charles M. A. P.
dc.contributor.authorNoben, Jean-Paul
dc.contributor.authorO'Sullivan, Tadhg
dc.contributor.authorBoer, Viktor
dc.contributor.authorvan Sinderen, Douwe
dc.contributor.funderIrish Research Councilen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-10-23T04:48:38Z
dc.date.available2019-10-23T04:48:38Z
dc.date.issued2019-10-16
dc.description.abstractLactobacillus brevis is a lactic acid bacterium that is known as a food and beverage spoilage organism, and more specifically as a beer-spoiler. Phages of L. brevis have been described, but very limited data is available regarding temperate phages of L. brevis. Temperate phages may exert benefits to the host, while they may also be employed to combat beer spoilage. The current study reports on the incidence of prophage sequences present in nineteen distinct L. brevis genomes. Prophage induction was evaluated using mitomycin C exposure followed by genome targeted-PCR, electron microscopy and structural proteome analysis. The morphological and genome sequence analyses revealed significant diversity among L. brevis prophages, which appear to be dominated by members of the Myoviridae phage family. Based on this analysis, we propose a classification of L. brevis phages into five groups.en
dc.description.sponsorshipIrish Research Council (Enterprise Partnership Scheme postgraduate scholarship (Ref. No. EPSPG/2015/7))en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid2396en
dc.identifier.citationFeyereisen, M., Mahony, J., Neve, H., Franz, C. M. A. P., Noben, J.-P., O’Sullivan, T., Boer, V. and van Sinderen, D. (2019) 'Biodiversity and Classification of Phages Infecting Lactobacillus brevis', Frontiers in Microbiology, 10, 2396. (12pp.) DOI: 10.3389/fmicb.2019.02396en
dc.identifier.doi10.3389/fmicb.2019.02396en
dc.identifier.eissn1664-302X
dc.identifier.endpage12en
dc.identifier.journaltitleFrontiers in Microbiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8836
dc.identifier.volume10en
dc.language.isoenen
dc.publisherFrontiers Mediaen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Investigator Programme/13/IA/1953/IE/Functional analysis of the host adsorption and DNA injection processes of a lactococcal bacteriophage/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/15/SIRG/3430/IE/Phage-host interactome of the dairy bacterium Streptococcus thermophilus (PHIST)/en
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fmicb.2019.02396/full
dc.rights© 2019 Feyereisen, Mahony, Neve, Franz, Noben, O’Sullivan, Boer and van Sinderen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectLactic acid bacteriaen
dc.subjectBeer spoilageen
dc.subjectBacteriophageen
dc.subjectLysogenyen
dc.subjectProphageen
dc.subjectGenomic analysisen
dc.subjectInductionen
dc.subjectMyoviridaeen
dc.titleBiodiversity and classification of phages infecting Lactobacillus brevisen
dc.typeArticle (peer-reviewed)en
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