Antifungal peptides as therapeutic agents
| dc.contributor.author | Fernández de Ullivarri, Miguel | en |
| dc.contributor.author | Arbulu, Sara | en |
| dc.contributor.author | Garcia-Gutierrez, Enriqueta | en |
| dc.contributor.author | Cotter, Paul D. | en |
| dc.contributor.funder | Science Foundation Ireland | en |
| dc.contributor.funder | Horizon 2020 | en |
| dc.contributor.funder | Teagasc | en |
| dc.date.accessioned | 2023-05-31T08:31:03Z | |
| dc.date.available | 2023-05-31T08:31:03Z | |
| dc.date.issued | 2020-03-17 | en |
| dc.description.abstract | Fungi have been used since ancient times in food and beverage-making processes and, more recently, have been harnessed for the production of antibiotics and in processes of relevance to the bioeconomy. Moreover, they are starting to gain attention as a key component of the human microbiome. However, fungi are also responsible for human infections. The incidence of community-acquired and nosocomial fungal infections has increased considerably in recent decades. Antibiotic resistance development, the increasing number of immunodeficiency- and/or immunosuppression-related diseases and limited therapeutic options available are triggering the search for novel alternatives. These new antifungals should be less toxic for the host, with targeted or broader antimicrobial spectra (for diseases of known and unknown etiology, respectively) and modes of actions that limit the potential for the emergence of resistance among pathogenic fungi. Given these criteria, antimicrobial peptides with antifungal properties, i.e., antifungal peptides (AFPs), have emerged as powerful candidates due to their efficacy and high selectivity. In this review, we provide an overview of the bioactivity and classification of AFPs (natural and synthetic) as well as their mode of action and advantages over current antifungal drugs. Additionally, natural, heterologous and synthetic production of AFPs with a view to greater levels of exploitation is discussed. Finally, we evaluate the current and potential applications of these peptides, along with the future challenges relating to antifungal treatments. | en |
| dc.description.sponsorship | Teagasc (Walsh Fellowship Project 2015066) | en |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Published Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.articleid | 105 | en |
| dc.identifier.citation | Fernández de Ullivarri, M., Arbulu, S., Garcia-Gutierrez, E. and Cotter, P. D. (2020) 'Antifungal peptides as therapeutic agents', Frontiers in Cellular and Infection Microbiology, 10, 105 (22pp). doi: 10.3389/fcimb.2020.00105 | en |
| dc.identifier.doi | 10.3389/fcimb.2020.00105 | en |
| dc.identifier.endpage | 22 | en |
| dc.identifier.issn | 2235-2988 | en |
| dc.identifier.journaltitle | Frontiers in Cellular and Infection Microbiology | en |
| dc.identifier.startpage | 1 | en |
| dc.identifier.uri | https://hdl.handle.net/10468/14524 | |
| dc.identifier.volume | 10 | en |
| dc.language.iso | en | en |
| dc.publisher | Frontiers Media | en |
| dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ | en |
| dc.relation.project | info:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/754535/EU/APC Postdoctoral EXcellence Programme/APEX | en |
| dc.rights | © 2020, Fernández de Ullivarri, Arbulu, Garcia-Gutierrez and Cotter. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | Antifungal peptides | en |
| dc.subject | Antimicrobial peptides | en |
| dc.subject | Mycoses | en |
| dc.subject | Antimicrobial resistance | en |
| dc.subject | Production | en |
| dc.subject | New therapies | en |
| dc.title | Antifungal peptides as therapeutic agents | en |
| dc.type | Article (peer-reviewed) | en |
| oaire.citation.volume | 10 | en |
