Quantification of human milk phospholipids: The effect of gestational and lactational age on phospholipid composition

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dc.contributor.authorIngvordsen Lindahl, Ida Emilie
dc.contributor.authorArtegoitia, Virginia M.
dc.contributor.authorDowney, Eimear
dc.contributor.authorO'Mahony, James A.
dc.contributor.authorO'Shea, Carol Anne
dc.contributor.authorRyan, C. Anthony
dc.contributor.authorKelly, Alan L.
dc.contributor.authorBertram, Hanne C.
dc.contributor.authorSundekilde, Ulrik K.
dc.contributor.funderAarhus Universiteten
dc.date.accessioned2019-11-20T06:10:38Z
dc.date.available2019-11-20T06:10:38Z
dc.date.issued2019-01-22
dc.description.abstractHuman milk (HM) provides infants with macro- and micronutrients needed for growth and development. Milk phospholipids are important sources of bioactive components, such as long-chain polyunsaturated fatty acids (LC-PUFA) and choline, crucial for neural and visual development. Milk from mothers who have delivered prematurely (<37 weeks) might not meet the nutritional requirements for optimal development and growth. Using liquid chromatography tandem-mass spectrometry, 31 phospholipid (PL) species were quantified for colostrum (<5 days postpartum), transitional (≥5 days and ≤2 weeks) and mature milk (>2 weeks and ≤15 weeks) samples from mothers who had delivered preterm (n = 57) and term infants (n = 22), respectively. Both gestational age and age postpartum affected the PL composition of HM. Significantly higher concentrations (p < 0.05) of phosphatidylcholine (PC), sphingomyelin (SM) and total PL were found in preterm milk throughout lactation, as well as significantly higher concentrations (p < 0.002) of several phosphatidylethanolamine (PE), PC and SM species. Multivariate analysis revealed that PLs containing LC-PUFA contributed highly to the differences in the PL composition of preterm and term colostrum. Differences related to gestation decreased as the milk matured. Thus, gestational age may impact the PL content of colostrum, however this effect of gestation might subside in mature milk.en
dc.description.sponsorshipGrant 2017-524en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid222en
dc.identifier.citationLindahl, I., Emilie, I., Artegoitia, V.M., Downey, E., O’Mahony, J.A., O’Shea, C.A., Ryan, C.A., Kelly, A.L., Bertram, H.C. and Sundekilde, U.K., 2019. Quantification of Human Milk Phospholipids: The Effect of Gestational and Lactational Age on Phospholipid Composition. Nutrients, 11(2), (222). DOI:10.3390/nu11020222en
dc.identifier.doi10.3390/nu11020222en
dc.identifier.eissn2072-6643
dc.identifier.endpage14en
dc.identifier.issn2072-6643
dc.identifier.issued2en
dc.identifier.journaltitleNutrientsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9164
dc.identifier.volume11en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urihttps://www.mdpi.com/2072-6643/11/2/222
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerlanden
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectHuman milken
dc.subjectPreterm infanten
dc.subjectPhospholipidsen
dc.subjectLipidomicsen
dc.subjectMilk fat globule membraneen
dc.titleQuantification of human milk phospholipids: The effect of gestational and lactational age on phospholipid compositionen
dc.typeArticle (peer-reviewed)en
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