Diversity of gut microbiota and bifidobacterial community of Chinese subjects of different ages and from different regions

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dc.contributor.authorYang, Bo
dc.contributor.authorYan, Shuang
dc.contributor.authorChen, Yang
dc.contributor.authorRoss, R. Paul
dc.contributor.authorStanton, Catherine
dc.contributor.authorZhao, Jianxin
dc.contributor.authorZhang, Hao
dc.contributor.authorChen, Wei
dc.contributor.funderNational Natural Science Foundation of Chinaen
dc.contributor.funderNational First-Class Discipline Program of Food Science and Technologyen
dc.contributor.funderFundamental Research Funds for the Central Universitiesen
dc.contributor.funderCollaborative Innovationcenter of Food Safety and Quality Control in Jiangsu Provinceen
dc.date.accessioned2023-02-16T10:11:36Z
dc.date.available2023-02-16T10:11:36Z
dc.date.issued2020-08
dc.date.updated2023-02-16T09:55:37Z
dc.description.abstractGut microbiota composition and functionality are closely linked to host health. In this study, the fecal microbiota and bifidobacterial communities of 111 healthy volunteers from four regions of China of varying age profiles (Child, 1-5 years; Young, 18-50 years; Elder, 60-80 years; Longevity, ≥90 years) were investigated via high-throughput sequencing. Canonical analysis revealed that the gut microbiota, as well as bifidobacteria profiles of the subjects, clustered according to their regions and age. Eight genera were shared among all subjects, however, certain genera distributed differently in subjects grouped by region and age. Faecalibacterium was enriched in samples from Zhongxiang, unclassified Ruminococcaceae and Christensenellaceae were enriched in the Longevity group, and Bifidobacterium was enriched in Child. Within Bifidobacterium, B. longum was the most abundant species in almost all samples except for Child, in which B. pseudocatenulatum was the most abundant. Additionally, the abundances of B. adolescentis and B. dentium were lower in Child. In conclusion, our results suggest that geography and age affect the structure of the gut microbiota, as well as Bifidobacterium composition, and this variation may greatly associate with the metabolic and immune changes that occur during the process of aging.en
dc.description.sponsorshipNational Natural Science Foundation of China (Grant numbers Nos. 31820103010, 31530056); National First-Class Discipline Program of Food Science and Technology (Grant number JUFSTR20180102); Fundamental Research Funds for the Central Universities (Grant number JUSRP52003B)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid1108en
dc.identifier.citationYang, B., Yan, S., Chen, Y., Ross, R.P., Stanton, C., Zhao, J., Zhang, H. and Chen, W. (2020) ‘Diversity of gut microbiota and bifidobacterial community of Chinese subjects of different ages and from different regions’, Microorganisms, 8(8),1108 (18pp). doi:10.3390/microorganisms8081108en
dc.identifier.doi10.3390/microorganisms8081108en
dc.identifier.endpage18en
dc.identifier.issn2076-2607
dc.identifier.issued8en
dc.identifier.journaltitleMicroorganismsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/14223
dc.identifier.volume8en
dc.language.isoenen
dc.publisherMDPIen
dc.rights© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAgeen
dc.subjectBifidobacterial communityen
dc.subjectChinese subjectsen
dc.subjectDiversityen
dc.subjectGut microbiotaen
dc.subjectRegionen
dc.titleDiversity of gut microbiota and bifidobacterial community of Chinese subjects of different ages and from different regionsen
dc.typeArticle (peer-reviewed)en
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