Oral delivery of non-viral nucleic acid-based therapeutics - do we have the guts for this?

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dc.contributor.authorO'Driscoll, Caitríona M.
dc.contributor.authorBernkop-Schnürch, Andreas
dc.contributor.authorFriedl, Julian D.
dc.contributor.authorPréat, Véronique
dc.contributor.authorJannin, Vincent
dc.contributor.funderEuropean Cooperation in Science and Technologyen
dc.date.accessioned2019-11-19T12:07:33Z
dc.date.available2019-11-19T12:07:33Z
dc.date.issued2019-05-15
dc.description.abstractGene therapy with RNA and pDNA-based drugs is limited by poor enzymatic stability and poor cellular permeation. The delivery of nucleic acids, in particular by the oral route, remains a major hurdle. This review will focus on the barriers to the oral delivery of nucleic acids and the strategies, in particular formulation strategies, which have been developed to overcome these barriers. Due to their very low oral bioavailability, the most obvious and most investigated biomedical applications for their oral delivery are related to the local treatment of inflammatory bowel diseases and colorectal cancers. Preclinical data but not yet clinical studies support the potential use of the oral route for the local delivery of formulated nucleic acid-based drugs.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Driscoll, C.M., Bernkop-Schnürch, A., Friedl, J.D., Préat, V. and Jannin, V., 2019. Oral delivery of non-viral nucleic acid-based therapeutics-do we have the guts for this?. European Journal of Pharmaceutical Sciences, 133, (14pp). DOI:10.1016/j.ejps.2019.03.027en
dc.identifier.doi10.1016/j.ejps.2019.03.027en
dc.identifier.eissn1879-0720
dc.identifier.endpage204en
dc.identifier.issn0928-0987
dc.identifier.journaltitleEuropean Journal of Pharmaceutical Sciencesen
dc.identifier.startpage190en
dc.identifier.urihttps://hdl.handle.net/10468/9083
dc.identifier.volume133en
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0928098719301368?via%3Dihub
dc.rights© 2019 The Authors. Published by Elsevier B.V.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectNucleic aciden
dc.subjectOral deliveryen
dc.subjectRNAen
dc.subjectpDNAen
dc.subjectNanoparticlesen
dc.subjectLipid-based particlesen
dc.subjectInflammatory bowel diseaseen
dc.titleOral delivery of non-viral nucleic acid-based therapeutics - do we have the guts for this?en
dc.typeArticle (peer-reviewed)en
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