The significance of Notch ligand expression in the peripheral blood of children with hand, foot and mouth disease (HFMD)

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dc.contributor.authorBai, Zhen Jiang
dc.contributor.authorLi, Yi Ping
dc.contributor.authorHuang, Jie
dc.contributor.authorXiang, Yong Jun
dc.contributor.authorLu, Chun Yu
dc.contributor.authorKong, Xiao Xing
dc.contributor.authorTian, Jian Mei
dc.contributor.authorWang, Jiang Huai
dc.contributor.authorWang, Jian
dc.contributor.funderNational Natural Science Foundation of Chinaen
dc.contributor.funderNational Natural Science Foundation of Jiangsu Province, Chinaen
dc.contributor.funderInnovative Team of Jiangsu Province, Chinaen
dc.contributor.funderJiangsu Province Program of Innovative and Entrepreneurial Talents, Chinaen
dc.date.accessioned2016-01-25T15:20:08Z
dc.date.available2016-01-25T15:20:08Z
dc.date.issued2014-06-17
dc.description.abstractBACKGROUND: Hand, foot and mouth disease (HFMD), a virus-induced infectious disease that usually affects infants and children, has an increased incidence in China in recent years. This study attempted to investigate the role of the Notch signaling pathway in the pathogenesis of HFMD. METHODS: Eighty-two children diagnosed with HFMD were enrolled into this study. The HFMD group was further divided into the uncomplicated HFMD and HFMD with encephalitis groups. The control group included 40 children who underwent elective surgery for treatment of inguinal hernias. RESULTS: Children with HFMD displayed significantly reduced CD3+, CD3+CD4+ and CD3+CD8+ cell subsets, but substantially enhanced CD3−CD19+ cell subset (p < 0.05 versus control subjects). The expression levels of Notch ligands Dll1 and Dll4 in the peripheral blood of the HFMD group were significantly higher than those in the control group (p < 0.05). There were statistically significant differences in CD3+, CD3+CD4+ and CD3−CD19+ cell subsets, but not in Notch ligand expression, between the uncomplicated HFMD and HFMD with encephalitis groups. Dll4 expression in HFMD subjects correlated negatively with the CD3+ and CD3+CD8+ cell subsets (p < 0.05), but positively with the CD3−CD19+ cell subset (p < 0.05). Furthermore, Dll4 expression in HFMD with encephalitis subjects correlated positively with total white blood cell (WBC) counts and total protein contents in cerebrospinal fluid (CSF) (p < 0.05). CONCLUSIONS: The Notch ligand Dll4 exhibits a strong correlation with the CD3+, CD3+CD8+ and CD3−CD19+ cell subsets in children with HFMD, indicating that the Notch signaling may be involved in the development of HFMD by affecting the number and status of peripheral lymphocytes.en
dc.description.sponsorshipNational Natural Science Foundation of China (Grant 81272143); National Natural Science Foundation of Jiangsu Province (Grant BK2011310); Innovative Team of Jiangsu Province, China (Grant LJ201141); Jiangsu Province Program of Innovative and Entrepreneurial Talents (2011- 2014)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid337
dc.identifier.articleid337
dc.identifier.citationBAI, Z. J., LI, Y. P., HUANG, J., XIANG, Y. J., LU, C. Y., KONG, X. X., TIAN, J. M., WANG, J. H. & WANG, J. 2014. The significance of Notch ligand expression in the peripheral blood of children with hand, foot and mouth disease (HFMD). BMC Infectious Diseases, 14: 337, 1-7. http://dx.doi.org/10.1186/1471-2334-14-337en
dc.identifier.doi10.1186/1471-2334-14-337
dc.identifier.endpage7en
dc.identifier.issn1471-2334
dc.identifier.journaltitleBMC Infectious Diseasesen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/2210
dc.identifier.volume14en
dc.language.isoenen
dc.publisherBiomed Central Ltd.en
dc.rights© 2014 Bai et al.; licensee BioMed Central Ltd, 2014. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.en
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/en
dc.subjectNotch signalingen
dc.subjectSubsets of T lymphocytesen
dc.subjectHand foot and mouth diseaseen
dc.subjectHFMDen
dc.subjectChildrenen
dc.subjectBrainstem encephalitisen
dc.subjectPulmonary edemaen
dc.subjectPathogenesisen
dc.subjectActivationen
dc.subjectDifferentiationen
dc.subjectEnterovirus 71en
dc.subjectEV71en
dc.subjectComplicationsen
dc.subjectMortalityen
dc.subjectMechanismen
dc.subjectCytokinesen
dc.titleThe significance of Notch ligand expression in the peripheral blood of children with hand, foot and mouth disease (HFMD)en
dc.typeArticle (peer-reviewed)en
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