Hospitalisation and adverse drug events in a geriatric oncology setting: A systematic review of the literature

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dc.check.date2025-05-01en
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisheren
dc.contributor.authorWalsh, Darren J.en
dc.contributor.authorO'Driscoll, Michelleen
dc.contributor.authorHorgan, Anne M.en
dc.contributor.authorTabb, Eoinen
dc.contributor.authorHannan, Michelleen
dc.contributor.authorMorris, Coletteen
dc.contributor.authorSahm, Laura J.en
dc.date.accessioned2024-06-06T11:13:24Z
dc.date.available2024-06-06T11:13:24Z
dc.date.issued2024-05-01en
dc.description.abstractBackground: Geriatric Oncology is a specialty where a multidisciplinary approach can address the unmet needs of older adults with cancer. Older adults are at increased risk of adverse drug events (ADE) due to age-related changes in pharmacokinetics and pharmacodynamics, increasing treatment complexity, and medication burden. Objectives: To review the literature to determine the incidence of unplanned hospitalisation due to ADE for all medications, both systemic anticancer therapy (SACT) and non-SACT medications. Methods: A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. The search included the following databases: PubMed, CINAHL, and Embase. A manual search of Scopus was then performed. Study quality was assessed using the Cochrane Handbook for Systematic Reviews of Interventions, Mixed Methods Appraisal Tool (MMAT) and Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework. Results: Overall, three studies were included. One observational study reported 19 % of unplanned hospital admissions due to ADE in patients aged ≥70 years with cancer. The first retrospective study reported 24 % of unplanned hospital admissions are due to ADE in patients aged ≥70 years with cancer, and the second retrospective study reported 26 % of patients with metastatic melanoma treated with immune checkpoint inhibitors had an unplanned hospital admission due to an ADE. Conclusion: There is a paucity of studies assessing unplanned hospitalisation due to ADE in older adults with cancer. Future studies are needed and should account for the reporting of potential ADE relative to supportive care, ancillary medications, and indeed chronic medications used to treat long-standing comorbidities.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationWalsh, D. J., O’Driscoll, M., Horgan, A. M., Tabb, E., Hannan, M., Morris, C. and Sahm, L. J. (2024) 'Hospitalisation and adverse drug events in a geriatric oncology setting: A systematic review of the literature', Research in Social and Administrative Pharmacy. https://doi.org/10.1016/j.sapharm.2024.04.018en
dc.identifier.doihttps://doi.org/10.1016/j.sapharm.2024.04.018en
dc.identifier.issn1551-7411en
dc.identifier.journaltitleResearch in Social and Administrative Pharmacyen
dc.identifier.urihttps://hdl.handle.net/10468/15992
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.rights© 2024, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectDrug-related side effects and adverse reactionsen
dc.subjectSystematic reviewen
dc.subjectPolypharmacyen
dc.subjectUnplanned hospitalisationen
dc.subjectGeriatric oncologyen
dc.titleHospitalisation and adverse drug events in a geriatric oncology setting: A systematic review of the literatureen
dc.typeArticle (peer-reviewed)en
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