The effect of superoxide dismutase enzyme inhibition on renal microcirculation of spontaneously hypertensive-stroke prone and Wistar rats

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dc.contributor.authorAhmeda, A. F.
dc.contributor.authorRae, Mark G.
dc.contributor.authorAnweigi, L. M.
dc.contributor.authorAl Otaibi, M. F.
dc.contributor.authorAl-Masri, A. A.
dc.contributor.authorJohns, E. J.
dc.contributor.funderKing Saud University
dc.date.accessioned2023-06-07T14:35:06Z
dc.date.available2023-05-08T12:19:05Zen
dc.date.available2023-06-07T14:35:06Z
dc.date.issued2018-01en
dc.date.updated2023-05-08T11:19:06Zen
dc.description.abstractA significant factor in the development of hypertension may be excessive vasoconstriction within the renal medulla. This study therefore investigated the role of superoxide dismutase (SOD) in the regulation of renal medullary and cortical blood perfusion (MBP and CBP, respectively) in both stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar rats. CBP and MBP were measured before and after intra-renal infusion of the SOD inhibitor, diethyldithio-carbamic acid (DETC). Under basal conditions, mean arterial pressure was significantly greater in SHRSP than Wistar rats, but both MBP and heart rate (HR) were significantly lower in SHRSP relative to Wistar rats (P<0.05, n=7 in both groups). Infusion of DETC (2 mg/kg/min) into the cortico-medullary border area of the kidney significantly decreased MBP in the SHRSPs (by 28+/-3 %, n=7, P<0.05), indicating a greater vasoconstriction within this vascular bed. However, DETC also significantly decreased MBP in Wistar rats to a similar extent (24+/-4 %, n=7, P<0.05). These results suggest that superoxide anions play a significant role in reducing renal vascular compliance within the renal medulla in both normotensive and hypertensive animals, although the responses are not greater in the hypertensive relative to the control animals.
dc.description.sponsorshipKing Saud University (“Research Centre of the Female Scientific and Medical Colleges”, Deanship of Scientific Research)
dc.description.statusPeer revieweden
dc.description.versionPublished Version
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAhmeda, A.F., Rae, M.G., Anweigi, L.M., Al Otaibi, M.F., Al-Masri, A.A. and Johns, E.J. (2018) ‘The effect of superoxide dismutase enzyme inhibition on renal microcirculation of spontaneously hypertensive-stroke prone and wistar rats’, Physiological Research, pp. 535–541. https://doi.org/10.33549/physiolres.933655.
dc.identifier.doi10.33549/physiolres.933655
dc.identifier.endpage541
dc.identifier.issn0862-8408
dc.identifier.issued4
dc.identifier.journaltitlePhysiological Research
dc.identifier.startpage535
dc.identifier.urihttps://hdl.handle.net/10468/14547
dc.identifier.volume67
dc.language.isoenen
dc.publisherCzech Academy of Sciences
dc.rights© 2018 Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMedullary blood perfusion
dc.subjectDETC
dc.subjectReactive oxygen species
dc.subjectSHRSP
dc.subjectRenal microcirculation
dc.titleThe effect of superoxide dismutase enzyme inhibition on renal microcirculation of spontaneously hypertensive-stroke prone and Wistar rats
dc.typeArticle (peer-reviewed)en
dc.typeArticleen
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