The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults

Simple item page
dc.contributor.authorO'Neill, Colette M.
dc.contributor.authorMinihane, Anne-Marie
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen
dc.date.accessioned2018-01-30T12:26:15Z
dc.date.available2018-01-30T12:26:15Z
dc.date.issued2016-08-16
dc.description.abstractThe aim of this review was to determine the impact of the fatty acid desaturase (FADS) genotype on plasma and tissue concentrations of the long-chain (LC) n-3 PUFA, including EPA and DHA, which are associated with the risk of several diet-related chronic diseases, including CVD. In addition to dietary intakes, which are low for many individuals, tissue EPA and DHA are also influenced by the rate of bioconversion from α-linolenic acid (αLNA). Δ-5 and Δ-6 desaturase enzymes, encoded for by FADS1 and FADS2 genes, are key desaturation enzymes involved in the bioconversion of essential fatty acids (αLNA and linoleic acid (LA)) to longer chained PUFA. In general, carriers of FADS minor alleles tend to have higher habitual plasma and tissue levels of LA and αLNA, and lower levels of arachidonic acid, EPA and also to a lesser extent DHA. In conclusion, available research findings suggest that FADS minor alleles are also associated with reduced inflammation and CVD risk, and that dietary total fat and fatty acid intake have the potential to modify relationships between FADS gene variants and circulating fatty acid levels. However to date, neither the size-effects of FADS variants on fatty acid status, nor the functional SNP in FADS1 and 2 have been identified. Such information could contribute to the refinement and targeting of EPA and DHA recommendations, whereby additional LC n-3 PUFA intakes could be recommended for those carrying FADS minor alleles.en
dc.description.sponsorshipBiotechnology and Biological Sciences Research Council (BBSRC Institute Strategic Programme grant (BB/J004545/1))en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Neill, C. M. and Minihane, A.-M. (2016) 'The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults', Proceedings of the Nutrition Society, 76(1), pp. 64-75. doi: 10.1017/S0029665116000732en
dc.identifier.doi10.1017/S0029665116000732
dc.identifier.endpage75en
dc.identifier.issn0029-6651
dc.identifier.issued1en
dc.identifier.journaltitleProceedings of the Nutrition Societyen
dc.identifier.startpage64en
dc.identifier.urihttps://hdl.handle.net/10468/5348
dc.identifier.volume76en
dc.language.isoenen
dc.publisherCambridge University Press (CUP)en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/266486/EU/New dietary strategies addressing the specific needs of elderly population for an healthy ageing in Europe/NU-AGEen
dc.rights© The Authors 2016.en
dc.subjectEPAen
dc.subjectDHAen
dc.subjectArachidonic aciden
dc.subjectLong-chain PUFAen
dc.subjectGenotypeen
dc.subjectFADSen
dc.subjectCardiovascularen
dc.subjectCVDen
dc.subjectFatty acid desaturaseen
dc.subjectFatty aciden
dc.subjectCardiovascular healthen
dc.subjectα-linolenic aciden
dc.subjectLinoleic aciden
dc.titleThe impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adultsen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
4291.pdf
Size:
1.53 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Food and Nutritional Sciences - Journal Articles