Dietary quality determined by the Healthy Eating Index-2015 and biomarkers of chronic low-grade inflammation: a cross-sectional analysis in middle-to-older aged adults
| dc.contributor.author | Millar, Seán R. | |
| dc.contributor.author | Navarro, Pilar | |
| dc.contributor.author | Harrington, Janas M. | |
| dc.contributor.author | Perry, Ivan J. | |
| dc.contributor.author | Phillips, Catherine M. | |
| dc.contributor.funder | Health Research Board | en |
| dc.contributor.funder | Breakthrough Cancer Research | en |
| dc.date.accessioned | 2022-12-13T14:57:07Z | |
| dc.date.available | 2022-12-13T14:57:07Z | |
| dc.date.issued | 2021-01 | |
| dc.date.updated | 2022-12-13T14:39:17Z | |
| dc.description.abstract | Low-grade systemic inflammation is associated with a range of chronic diseases. Diet may modulate inflammation and represents a promising therapeutic target to reduce metabolic dysfunction. To date, no study has examined Healthy Eating Index-2015 (HEI-2015) diet score associations with biomarkers of inflammation. Thus, our objective was to assess relationships between the HEI-2015 score and a range of inflammatory biomarkers in a cross-sectional sample of 1989 men and women aged 46-73 years, to test the hypothesis that better dietary quality would be associated with more favourable circulating levels of inflammatory biomarkers. Pro-inflammatory cytokines, adipocytokines, acute-phase response proteins, coagulation factors and white blood cell counts were determined. Correlation and linear regression analyses were used to test HEI-2015 diet score relationships with biomarker concentrations. Higher dietary quality as determined by the HEI-2015 was associated with lower c-reactive protein (CRP) and interleukin 6 concentrations, white blood cell (WBC) counts and its constituents, adjusting for sex and age. Associations with CRP concentrations and WBC counts persisted in the fully adjusted models. No associations with complement component 3, tumour necrosis factor alpha, adiponectin, leptin, resistin or plasminogen activator inhibitor-1 levels were identified. Our data suggest that dietary quality, determined by the HEI-2015 score, in middle-to-older aged adults is associated with inflammatory biomarkers related to cardiometabolic health. | en |
| dc.description.sponsorship | Health Research Board (Grant number HRC/2007/13); Breakthrough Cancer Research (Reference: BCR-2018-07 PH-UCC) | en |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Published Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.articleid | 222 | en |
| dc.identifier.citation | Millar, S.R., Navarro, P., Harrington, J.M., Perry, I.J. and Phillips, C.M. (2021) ‘Dietary quality determined by the Healthy Eating Index-2015 and biomarkers of chronic low-grade inflammation: a cross-sectional analysis in middle-to-older aged adults’, Nutrients, 13 (1), 222, (14pp). https://doi.org/10.3390/nu13010222. | en |
| dc.identifier.doi | 10.3390/nu13010222 | en |
| dc.identifier.endpage | 14 | en |
| dc.identifier.issn | 2072-6643 | |
| dc.identifier.issued | 1 | en |
| dc.identifier.journaltitle | Nutrients | en |
| dc.identifier.startpage | 1 | en |
| dc.identifier.uri | https://hdl.handle.net/10468/13959 | |
| dc.identifier.volume | 13 | en |
| dc.language.iso | en | en |
| dc.publisher | MDPI | en |
| dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | en |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | Healthy eating index | en |
| dc.subject | Inflammation | en |
| dc.subject | Biomarkers | en |
| dc.title | Dietary quality determined by the Healthy Eating Index-2015 and biomarkers of chronic low-grade inflammation: a cross-sectional analysis in middle-to-older aged adults | en |
| dc.type | Article (peer-reviewed) | en |
