dc.contributor.author	Flemer, Burkhardt
dc.contributor.author	Gaci, Nadia
dc.contributor.author	Borrel, Guillaume
dc.contributor.author	Sanderson, Ian R.
dc.contributor.author	Chaudhary, Prem P.
dc.contributor.author	Tottey, William
dc.contributor.author	O'Toole, Paul W.
dc.contributor.author	Brugère, Jean-François
dc.contributor.funder	Clermont Université
dc.contributor.funder	Conseil Régional d'Auvergne
dc.contributor.funder	Ministère de l'Enseignement Supérieur et de la Recherche
dc.contributor.funder	Science Foundation Ireland
dc.date.accessioned	2018-07-18T11:56:21Z
dc.date.available	2018-07-18T11:56:21Z
dc.date.issued	2017
dc.description.abstract	Laboratory rats are commonly used in life science research as a model for human biology and disease, but the composition and development of their gut microbiota during life is poorly understood. We determined the fecal microbiota composition of healthy Sprague Dawley laboratory rats from 3 weeks to 2 y of age, kept under controlled environmental and dietary conditions. Additionally, we determined fecal short-chain fatty acid profiles, and we compared the rat fecal microbiota with that of mice and humans. Gut microbiota and to a lesser extent SCFAs profiles separated rats into 3 different clusters according to age: before weaning, first year of life (12-to 26-week-old animals) and second year of life (52-to 104-week-old). A core of 46 bacterial species was present in all rats but its members' relative abundance progressively decreased with age. This was accompanied by an increase of microbiota alpha-diversity, likely due to the acquisition of environmental microorganisms during the lifespan. Contrastingly, the functional profile of the microbiota across animal species became more similar upon aging. Lastly, the microbiota of rats and mice were most similar to each other but at the same time the microbiota profile of rats was more similar to that of humans than was the microbiota profile of mice. These data offer an explanation as to why germ-free rats are more efficient recipients and retainers of human microbiota than mice. Furthermore, experimental design should take into account dynamic changes in the microbiota of model animals considering that their changing gut microbiota interacts with their physiology.	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Flemer, B., Gaci, N., Borrel, G., Sanderson, I. R., Chaudhary, P. P., Tottey, W., O'Toole, P. W. and Brugère, J.-F. (2017) 'Fecal microbiota variation across the lifespan of the healthy laboratory rat', Gut Microbes, 8(5), pp. 428-439. doi: 10.1080/19490976.2017.1334033	en
dc.identifier.doi	10.1080/19490976.2017.1334033
dc.identifier.endpage	439
dc.identifier.issn	1949-0976
dc.identifier.issued	5
dc.identifier.journaltitle	Gut Microbes	en
dc.identifier.startpage	428
dc.identifier.uri	https://hdl.handle.net/10468/6477
dc.identifier.volume	8
dc.language.iso	en	en
dc.publisher	Taylor & Francis Inc	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.uri	https://www.tandfonline.com/doi/full/10.1080/19490976.2017.1334033
dc.rights	© 2017, Burkhardt Flemer, Nadia Gaci, Guillaume Borrel, Ian R. Sanderson, Prem P. Chaudhary, William Tottey, Paul W. O'Toole, and Jean-Francois Brugere. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way	en
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject	Gut microbiota	en
dc.subject	Human biologic model	en
dc.subject	Lifespan evolution	en
dc.subject	Rat	en
dc.subject	Rattus norvegicus	en
dc.title	Fecal microbiota variation across the lifespan of the healthy laboratory rat	en
dc.type	Article (peer-reviewed)	en

Fecal microbiota variation across the lifespan of the healthy laboratory rat

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