CT in the detection of latent tuberculosis: a systematic review

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dc.check.date2024-05-13en
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisheren
dc.contributor.authorMoore, Niamhen
dc.contributor.authorMaher, M.en
dc.contributor.authorMurphy, G.en
dc.contributor.authorO’Callaghan Maher, M.en
dc.contributor.authorO’Connor, O. J.en
dc.contributor.authorMcEntee, Mark F.en
dc.date.accessioned2023-05-17T14:12:49Z
dc.date.available2023-05-17T14:12:49Z
dc.date.issued2023-05-13en
dc.description.abstractAim: To evaluate the use of computed tomography (CT) and low-dose CT in the detection of latent tuberculosis (TB). Materials And Methods: A systematic search of literature in adherence with the PRISMA guidelines was carried out. Quality assessment of the included studies was conducted. Results: The search strategy identified a total of 4,621 studies. Sixteen studies were considered eligible and included in the review. There was high heterogeneity among all studies. CT was identified as much more sensitive for the detection of latent TB in all studies despite chest radiography often being recommended in guidelines to assess patients for latent TB. Low-dose CT showed promising results in four of the studies; however, these results were limited due to small sample sizes. Conclusion: CT is much superior to chest radiography consistently identifying additional cases of latent TB. There are limited high-quality publications available using low-dose CT but findings thus far suggest low-dose CT could be used as an alternative to standard-dose CT for the detection of latent TB. It is recommended that a randomised controlled trial investigating low-dose CT should be carried out.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMoore, N., Maher, M., Murphy, G., Maher, M. C., O’Connor, O. J. and McEntee, M. F. (2023) 'CT in the detection of latent tuberculosis: a systematic review', Clinical Radiology. doi: 10.1016/j.crad.2023.04.014en
dc.identifier.doi10.1016/j.crad.2023.04.014en
dc.identifier.eissn1365-229Xen
dc.identifier.issn0009-9260en
dc.identifier.journaltitleClinical Radiologyen
dc.identifier.urihttps://hdl.handle.net/10468/14476
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.rights© 2023, Published by Elsevier Ltd on behalf of The Royal College of Radiologists. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectLatent tuberculosisen
dc.subjectTBen
dc.subjectComputed tomographyen
dc.subjectCTen
dc.titleCT in the detection of latent tuberculosis: a systematic reviewen
dc.typeArticle (peer-reviewed)en
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