Harnessing marine biocatalytic reservoirs for green chemistry applications through metagenomic technologies

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dc.contributor.authorCastilla, Ignacio Abreu
dc.contributor.authorWoods, David F.
dc.contributor.authorReen, F. Jerry
dc.contributor.authorO'Gara, Fergal
dc.contributor.funderEnterprise Ireland
dc.contributor.funderEuropean Commission
dc.contributor.funderScience Foundation Ireland
dc.contributor.funderDepartment of Agriculture, Food and the Marine
dc.contributor.funderIrish Research Council for Science, Engineering and Technology
dc.contributor.funderHealth Research Board
dc.contributor.funderIrish Thoracic Society
dc.date.accessioned2018-08-29T15:47:27Z
dc.date.available2018-08-29T15:47:27Z
dc.date.issued2018
dc.description.abstractIn a demanding commercial world, large-scale chemical processes have been widely utilised to satisfy consumer related needs. Chemical industries are key to promoting economic growth and meeting the requirements of a sustainable industrialised society. The market need for diverse commodities produced by the chemical industry is rapidly expanding globally. Accompanying this demand is an increased threat to the environment and to human health, due to waste produced by increased industrial production. This increased demand has underscored the necessity to increase reaction efficiencies, in order to reduce costs and increase profits. The discovery of novel biocatalysts is a key method aimed at combating these difficulties. Metagenomic technology, as a tool for uncovering novel biocatalysts, has great potential and applicability and has already delivered many successful achievements. In this review we discuss, recent developments and achievements in the field of biocatalysis. We highlight how green chemistry principles through the application of biocatalysis, can be successfully promoted and implemented in various industrial sectors. In addition, we demonstrate how two novel lipases/esterases were mined from the marine environment by metagenomic analysis. Collectively these improvements can result in increased efficiency, decreased energy consumption, reduced waste and cost savings for the chemical industry.en
dc.description.sponsorshipEnterprise Ireland (CF-2017-0757-P); Department of Agriculture and Food (FIRM 1/F009/MabS, FIRM 13/F/516); Irish Research Council for Science, Engineering and Technology (GOIPG/2014/647); Health Research Board/Irish Thoracic Society (MRCG-2014-6)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid227
dc.identifier.citationCastilla, I., Woods, D., Reen, F. and O’Gara, F. (2018) 'Harnessing marine biocatalytic reservoirs for green chemistry applications through metagenomic technologies', Marine Drugs, 16(7), 227 (21pp). doi: 10.3390/md16070227en
dc.identifier.doi10.3390/md16070227
dc.identifier.endpage21
dc.identifier.issn1660-3397
dc.identifier.issued7
dc.identifier.journaltitleMarine Drugsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/6676
dc.identifier.volume16
dc.language.isoenen
dc.publisherMDPIen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/607786/EU/BluePharmTrain/BLUEPHARMTRAIN
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/312184/EU/Increasing Value and Flow in the Marine Biodiscovery Pipeline/PHARMASEA
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/311975/EU/Marine Microorganisms: Cultivation Methods for Improving their Biotechnological Applications/MACUMBA
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/287589/EU/Marine Microbial Biodiversity, Bioinformatics and Biotechnology/MICRO B3
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::IA/634486/EU/Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea/INMARE
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/13/TIDA/B2625/IE/Small molecule inhibitors of HIF-1: a new class of anti-cancer therapeutics./
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2411/IE/Development of small molecule therapeutics for medical intervention: anti-biofilm inhibitors for the medical device sector./
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2405/IE/Optimised detection of key biomarkers of Pseudomonas aeruginosa towards a clinical application/
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/14/TIDA/2438/IE/Next Generation Antibiotics: anti-biofilm, anti-pathogenic natural bioactives from marine microorganisms./
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/15/TIDA/2977/IE/Pre-clinical testing of novel fungal biofilm blockers for the medical device sector./
dc.relation.urihttp://www.mdpi.com/1660-3397/16/7/227
dc.rights© 2018, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGreen chemistryen
dc.subjectChemical industriesen
dc.subjectBiocatalysisen
dc.subjectMetagenomicsen
dc.subjectMarineen
dc.subjectBiodiscoveryen
dc.subjectLipaseen
dc.subjectEsteraseen
dc.titleHarnessing marine biocatalytic reservoirs for green chemistry applications through metagenomic technologiesen
dc.typeReviewen
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