Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease

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dc.contributor.authorStockdale, Stephen R.en
dc.contributor.authorDraper, Lorraine A.en
dc.contributor.authorO'Donovan, Sarahen
dc.contributor.authorBarton, Wileyen
dc.contributor.authorO'Sullivan, Orlaen
dc.contributor.authorVolpicelli-Daley, Laura A.en
dc.contributor.authorSullivan, Aideen M.en
dc.contributor.authorO'Neill, Coraen
dc.contributor.authorHill, Colinen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2024-04-04T12:45:43Z
dc.date.available2024-04-04T12:45:43Z
dc.date.issued2021en
dc.description.abstractParkinson’s disease (PD) is a chronic neurological disorder associated with the misfolding of alpha-synuclein (α-syn) into aggregates within nerve cells that contribute to their neurodegeneration. Recent evidence suggests α-syn aggregation may begin in the gut and travel to the brain along the vagus nerve, with microbes potentially a trigger initiating α-syn misfolding. However, the effects α-syn alterations on the gut virome have not been investigated. In this study, we show longitudinal faecal virome changes in rats administered either monomeric or preformed fibrils (PFF) of α-syn directly into their enteric nervous system. Differential changes in rat viromes were observed when comparing monomeric and PFF α-syn, with alterations compounded by the addition of LPS. Changes in rat faecal viromes were observed after one month and did not resolve within the study’s five-month observational period. These results suggest that virome alterations may be reactive to host α-syn changes that are associated with PD development.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid1140en
dc.identifier.citationStockdale, S.R., Draper, L.A., O’Donovan, S.M., Barton, W., O’Sullivan, O., Volpicelli-Daley, L.A., Sullivan, A.M., O’Neill, C. and Hill, C. (2021) ‘Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease’, Communications Biology, 4(1), 1140 (12pp). doi: 10.1038/s42003-021-02666-1en
dc.identifier.doi10.1038/s42003-021-02666-1en
dc.identifier.eissn2399-3642en
dc.identifier.endpage12en
dc.identifier.issued1en
dc.identifier.journaltitleCommunications Biologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15766
dc.identifier.volume4en
dc.language.isoenen
dc.publisherNature Researchen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Spokes Programme/14/SP APC/B3032/IE/Gut Phageomics - Phage as diagnostics and/or therapeutics in IBD/en
dc.rights© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectFaecal viromes of ratsen
dc.subjectAlpha-synucleinen
dc.subjectParkinson’s diseaseen
dc.titleAlpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s diseaseen
dc.typeArticle (peer-reviewed)en
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