Fighting biofilms with lantibiotics and other groups of bacteriocins

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dc.contributor.authorMathur, Harsh
dc.contributor.authorField, Des
dc.contributor.authorRea, Mary C.
dc.contributor.authorCotter, Paul D.
dc.contributor.authorHill, Colin
dc.contributor.authorRoss, R. Paul
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2018-09-06T10:39:34Z
dc.date.available2018-09-06T10:39:34Z
dc.date.issued2018
dc.description.abstractBiofilms are sessile communities of bacteria typically embedded in an extracellular polymeric matrix. Bacterial cells embedded in biofilms are inherently recalcitrant to antimicrobials, compared to cells existing in a planktonic state, and are notoriously difficult to eradicate once formed. Avenues to tackle biofilms thus far have largely focussed on attempting to disrupt the initial stages of biofilm formation, including adhesion and maturation of the biofilm. Such an approach is advantageous as the concentrations required to inhibit formation of biofilms are generally much lower than removing a fully established biofilm. The crisis of antibiotic resistance in clinical settings worldwide has been further exacerbated by the ability of certain pathogenic bacteria to form biofilms. Perhaps the most notorious biofilm formers described from a clinical viewpoint have been methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Pseudomonas aeruginosa, Gardnerella vaginalis and Streptococcus mutans, the latter of which is found in oral biofilms. Due to the dearth of novel antibiotics in recent decades, compounded by the increasing rate of emergence of resistance amongst pathogens with a propensity for biofilm formation, solutions are urgently required to mitigate these crises. Bacteriocins are a class of antimicrobial peptides, which are ribosomally synthesised and often are more potent than their antibiotic counterparts. Here, we review a selection of studies conducted with bacteriocins with the ultimate objective of inhibiting biofilms. Overall, a deeper understanding of the precise means by which a biofilm forms on a substrate as well as insights into the mechanisms by which bacteriocins inhibit biofilms is warranted.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid9
dc.identifier.citationMathur, H., Field, D., Rea, M. C., Cotter, P. D., Hill, C. and Ross, R. P. (2018) 'Fighting biofilms with lantibiotics and other groups of bacteriocins', npj Biofilms and Microbiomes, 4, 9 (13pp). doi: 10.1038/s41522-018-0053-6en
dc.identifier.doi10.1038/s41522-018-0053-6
dc.identifier.endpage13
dc.identifier.issn2055-5008
dc.identifier.journaltitleNpj Biofilms And Microbiomesen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/6723
dc.identifier.volume4
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.urihttps://www.nature.com/articles/s41522-018-0053-6
dc.rights© 2018, the Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPathogensen
dc.subjectBiofilmsen
dc.subjectAntimicrobialsen
dc.subjectBacteriocinsen
dc.subjectAntibioticen
dc.titleFighting biofilms with lantibiotics and other groups of bacteriocinsen
dc.typeArticle (peer-reviewed)en
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