Highly stable PEGylated gold nanoparticles in water: applications in biology and catalysis

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dc.contributor.authorRahme, Kamil
dc.contributor.authorNolan, Marie Therese
dc.contributor.authorDoody, Timothy
dc.contributor.authorMcGlacken, Gerard P.
dc.contributor.authorMorris, Michael A.
dc.contributor.authorO'Driscoll, Caitríona M.
dc.contributor.authorHolmes, Justin D.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHigher Education Authorityen
dc.date.accessioned2019-07-12T15:18:38Z
dc.date.available2019-07-12T15:18:38Z
dc.date.issued2013-08-21
dc.date.updated2019-06-28T15:38:21Z
dc.description.abstractHere we report the synthesis of well dispersed gold nanoparticles (Au NPs), with diameters ranging between 5 and 60 nm, in water and demonstrate their potential usefulness in catalysis and biological applications. Functionalised polyethylene glycol-based thiol polymers (mPEG-SH) were used to stabilise the pre-synthesised NPs. Successful PEGylation of the NPs was confirmed by Dynamic Light Scattering (DLS) and zeta potential measurements. PEG coating of the NPs was found to be key to their colloidal stability in high ionic strength media, compared to bare citrate-stabilised NPs. Our results show that PEG–Au NPs with diameters <30 nm were useful as catalysts in the homocoupling of arylboronic acids in water. Additionally, PEG–Au NPs were also shown to be stable in biological fluids, non-cytotoxic to B16.F10 and CT-26 cell lines and able to successfully deliver siRNA to CT-26 cells, achieving a significant reduction (p < 0.05) in the expression levels of luciferase protein; making these NPs attractive for further biological studies.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRahme, K., Nolan, M. T., Doody, T., McGlacken, G. P., Morris, M. A., O'Driscoll, C. and Holmes, J. D. (2013) 'Highly stable PEGylated gold nanoparticles in water: applications in biology and catalysis', RSC Advances, 3(43), pp. 21016-21024. doi: 10.1039/c3ra41873aen
dc.identifier.doi10.1039/c3ra41873aen
dc.identifier.endpage21024en
dc.identifier.issn*
dc.identifier.issued43en
dc.identifier.journaltitleRSC Advancesen
dc.identifier.startpage21016en
dc.identifier.urihttps://hdl.handle.net/10468/8160
dc.identifier.volume3en
dc.language.isoenen
dc.publisherRoyal Society of Chemistry (RSC)en
dc.relation.projectScience Foundation Ireland ((Grant 07/SRC/B1155 and 07/SRC/B1154) to the Irish Drug Delivery network (IDDN) through Strategic Research Cluster (SRC) grants); Higher Education Authority (HEA Program for Research in Third Level Institutions (2007–2011) via the INSPIRE programme)en
dc.relation.urihttps://pubs.rsc.org/en/content/articlepdf/2013/ra/c3ra41873a
dc.rights© Royal Society of Chemistry 2013en
dc.subjectCatalysisen
dc.subjectCell cultureen
dc.subjectDynamic light scatteringen
dc.subjectGolden
dc.subjectGold alloysen
dc.subjectIonic strengthen
dc.subjectMetal nanoparticlesen
dc.subjectMotion Picture Experts Group standardsen
dc.subjectBiological applicationsen
dc.subjectBiological fluidsen
dc.subjectBiological studiesen
dc.subjectColloidal Stabilityen
dc.subjectGold nanoparticleen
dc.subjectNanoparticlesen
dc.subjectHigh ionic strengthen
dc.subjectZeta potential measurementsen
dc.titleHighly stable PEGylated gold nanoparticles in water: applications in biology and catalysisen
dc.typeArticle (peer-reviewed)en
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