Clinical trials in hemodynamic support: past, present, and future

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dc.contributor.authorDempsey, Eugene M.
dc.contributor.authorEl-Khuffash, Afif
dc.contributor.funderSeventh Framework Programmeen
dc.date.accessioned2022-06-03T11:43:58Z
dc.date.available2022-06-03T11:43:58Z
dc.date.issued2020-09
dc.date.updated2022-06-03T11:30:06Z
dc.description.abstractManaging low blood flow states in the preterm population remains a challenge in neonatal clinical care. The heterogeneity of the trials to date and the relatively low number of infants enrolled, in addition to a desire to oversimplify the underlying pathophysiology, have contributed to an inability to draw meaningful conclusions to direct clinical care. This article reviews the current literature on this topic in the preterm population and outlines the challenges that have been encountered in performing such trials. Alternative studies are proposed, based on the lessons learned over the past number of years.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDempsey, E. M. and El-Khuffash, A. (2020) 'Clinical trials in hemodynamic support: past, present, and future', Clinics In Perinatology, 47 (3), pp. 641-652. doi: 10.1016/j.clp.2020.05.013en
dc.identifier.doi10.1016/j.clp.2020.05.013en
dc.identifier.endpage652en
dc.identifier.issn1557-9840
dc.identifier.issued3en
dc.identifier.journaltitleClinics In Perinatologyen
dc.identifier.startpage641en
dc.identifier.urihttps://hdl.handle.net/10468/13285
dc.identifier.volume47en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/260777/EU/Management of Hypotension In the Preterm Extremely Low Gestational Age Newborn/THE HIP TRIALen
dc.rights© 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectClinical trialsen
dc.subjectHypotensionen
dc.subjectInotropesen
dc.subjectLow blood flowen
dc.subjectPreterm infantsen
dc.titleClinical trials in hemodynamic support: past, present, and futureen
dc.typeArticle (peer-reviewed)en
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