Diagnostic MALDI-TOF MS can differentiate between high and low toxic Staphylococcus aureus bacteraemia isolates as a predictor of patient outcome

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dc.contributor.authorBrignoli, Tarcisio
dc.contributor.authorRecker, Mario
dc.contributor.authorLee, Winnie W. Y.
dc.contributor.authorDong, Tim
dc.contributor.authorBhamber, Ranjeet
dc.contributor.authorAlbur, Mahableshwar
dc.contributor.authorWilliams, Philip
dc.contributor.authorDowsey, Andrew W.
dc.contributor.authorMassey, Ruth C.
dc.contributor.funderWellcome Trusten
dc.contributor.funderThe Showering Funden
dc.contributor.funderMedical Research Councilen
dc.contributor.funderHealth Data Research UKen
dc.contributor.funderDepartment of Health and Social Careen
dc.date.accessioned2022-09-15T10:47:40Z
dc.date.available2022-09-15T10:47:40Z
dc.date.issued2022-08-23
dc.date.updated2022-09-15T09:17:35Z
dc.description.abstractStaphylococcus aureus bacteraemia (SAB) is a major cause of blood-stream infection (BSI) in both healthcare and community settings. While the underlying comorbidities of a patient significantly contributes to their susceptibility to and outcome following SAB, recent studies show the importance of the level of cytolytic toxin production by the infecting bacterium. In this study we demonstrate that this cytotoxicity can be determined directly from the diagnostic MALDI-TOF mass spectrum generated in a routine diagnostic laboratory. With further development this information could be used to guide the management and improve the outcomes for SAB patients.en
dc.description.sponsorshipWellcome Trust (Grant number: 212258/Z/18/Z); The Showering Fund (SF124); Medical Research Council (MR/T005408/1); Department of Health and Social Care (Health Data Research UK South-West Better Care Partnership AMR Site Project)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid001223en
dc.identifier.citationBrignoli, T., Recker, M., Lee, W. W. Y., Dong, T., Bhamber, R., Albur, M., Williams, P., Dowsey, A. W., Massey, Ruth C. (2022) 'Diagnostic MALDI-TOF MS can differentiate between high and low toxic Staphylococcus aureus bacteraemia isolates as a predictor of patient outcome'. Microbiology, 168(8), 001223 (6pp). doi: 10.1099/mic.0.001223en
dc.identifier.doi10.1099/mic.0.001223en
dc.identifier.eissn1465-2080
dc.identifier.endpage6en
dc.identifier.issn1350-0872
dc.identifier.issued8en
dc.identifier.journaltitleMicrobiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/13606
dc.identifier.volume168en
dc.language.isoenen
dc.publisherMicrobiology Societyen
dc.rights© 2022, The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAgren
dc.subjectBacteraemiaen
dc.subjectMALDI-TOF MS diagnosisen
dc.subjectStaphylococcus aureusen
dc.subjectToxicityen
dc.titleDiagnostic MALDI-TOF MS can differentiate between high and low toxic Staphylococcus aureus bacteraemia isolates as a predictor of patient outcomeen
dc.typeArticle (peer-reviewed)en
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