FIB patterning of stainless steel for the development of nano-structured stent surfaces for cardiovascular applications

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dc.contributor.authorSchmidt, Michael
dc.contributor.authorNazneen, F.
dc.contributor.authorGalvin, Paul
dc.contributor.authorPetkov, Nikolay
dc.contributor.authorHolmes, Justin D.
dc.contributor.editorWang, M. Z.
dc.contributor.funderHigher Education Authorityen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderNational Biophotonics and Imaging Platform Irelanden
dc.date.accessioned2016-04-20T14:04:31Z
dc.date.available2016-04-20T14:04:31Z
dc.date.issued2013-12-06
dc.date.updated2014-04-08T10:29:06Z
dc.description.abstractStent implantation is a percutaneous interventional procedure that mitigates vessel stenosis, providing mechanical support within the artery and as such a very valuable tool in the fight against coronary artery disease. However, stenting causes physical damage to the arterial wall. It is well accepted that a valuable route to reduce in-stent re-stenosis can be based on promoting cell response to nano-structured stainless steel (SS) surfaces such as by patterning nano-pits in SS. In this regard patterning by focused ion beam (FIB) milling offers several advantages for flexible prototyping. On the other hand FIB patterning of polycrystalline metals is greatly influenced by channelling effects and redeposition. Correlative microscopy methods present an opportunity to study such effects comprehensively and derive structure–property understanding that is important for developing improved patterning. In this chapter we present a FIB patterning protocol for nano-structuring features (concaves) ordered in rectangular arrays on pre-polished 316L stainless steel surfaces. An investigation based on correlative microscopy approach of the size, shape and depth of the developed arrays in relation to the crystal orientation of the underlying SS domains is presented. The correlative microscopy protocol is based on cross-correlation of top-view scanning electron microscopy, electron backscattering diffraction, atomic force microscopy and cross-sectional (serial) sectioning. Various FIB tests were performed, aiming at improved productivity by preserving nano-size accuracy of the patterned process. The optimal FIB patterning conditions for achieving reasonably high throughput (patterned rate of about 0.03 mm2/h) and nano-size accuracy in dimensions and shapes of the features are discussed as well.en
dc.description.sponsorshipScience Foundation Ireland (SFI Starting Investigator Research Grant (09/SIRG/I1621)); Higher Education Authority (INSPIRE Initiative)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSCHMIDT, M., NAZNEEN, F., GALVIN, P., PETKOV, N. & HOLMES, J. D. 2013. FIB Patterning of Stainless Steel for the Development of Nano-structured Stent Surfaces for Cardiovascular Applications. In: WANG, M. Z. (ed.) FIB Nanostructures. Cham: Springer International Publishing. http://dx.doi.org/10.1007/978-3-319-02874-3_16en
dc.identifier.doi10.1007/978-3-319-02874-3_16
dc.identifier.endpage416en
dc.identifier.isbn978-3-319-02874-3
dc.identifier.journaltitleLecture Notes in Nanoscale Science and Technologyen
dc.identifier.startpage391en
dc.identifier.urihttps://hdl.handle.net/10468/2468
dc.identifier.volume20en
dc.language.isoenen
dc.publisherSpringer International Publishingen
dc.relation.ispartofFIB Nanostructures - Lecture Notes in Nanoscale Science and Technology
dc.relation.urihttp://link.springer.com/chapter/10.1007/978-3-319-02874-3_16
dc.rights© Springer International Publishing Switzerland, 2013. The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-02874-3_16en
dc.subjectStentsen
dc.subjectFIBen
dc.subjectFocused ion beamen
dc.subjectPolycrystalline austenitic medical grade stainless steel 316L substrateen
dc.subjectNano-surface patterning with pitsen
dc.subjectConcavesen
dc.subjectHolesen
dc.subjectEndothelial cell adhesionen
dc.subjectCorrelative microscopyen
dc.subjectEBSDen
dc.subjectSEMen
dc.subjectAFMen
dc.subjectSerial FIB–SEM sectioningen
dc.titleFIB patterning of stainless steel for the development of nano-structured stent surfaces for cardiovascular applicationsen
dc.typeBook chapteren
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