Steroid-induced mental disorders in cancer patients: a systematic review

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dc.contributor.authorIsmail, Muhammad Fahmi
dc.contributor.authorLavelle, Clianna
dc.contributor.authorCassidy, Eugene M.
dc.date.accessioned2018-12-06T10:17:29Z
dc.date.available2018-12-06T10:17:29Z
dc.date.issued2017-11-30
dc.description.abstractCorticosteroids are a central part of many cancer treatment regimens. Neuropsychiatric toxicity has complicated their use, including an association with a spectrum of symptoms, from insomnia, cognitive impairment and mood symptoms, to severe mental disorders, including mania, psychosis and severe depression. Although steroid-induced mental disorders were first reported in medicine more than 60 years ago, there is a dearth of evidence available to date on optimal treatment and prevention to guide cancer clinicians. We completed a systematic review of the current evidence for therapeutic and prophylactic interventions of steroid-induced mental disorders in cancer. We searched Medline, Embase and PsycINFO and selected studies related to steroid-induced mental disorder. The studies found were limited to case series and case reports only.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationIsmail, M. F., Lavelle, C. and Cassidy, E. M. (2017) 'Steroid-induced mental disorders in cancer patients: a systematic review', Future Oncology, 13(29), pp. 2719-2731. doi: 10.2217/fon-2017-0306en
dc.identifier.doi10.2217/fon-2017-0306
dc.identifier.endpage2731en
dc.identifier.issn1479-6694
dc.identifier.issn1744-8301
dc.identifier.issued29en
dc.identifier.journaltitleFuture Oncologyen
dc.identifier.startpage2719en
dc.identifier.urihttps://hdl.handle.net/10468/7176
dc.identifier.volume13en
dc.language.isoenen
dc.publisherFuture Medicineen
dc.relation.urihttps://www.futuremedicine.com/doi/abs/10.2217/fon-2017-0306
dc.rights© 2017 Future Medicine. This is the Author’s Accepted Manuscript of a work published in Future Oncology. The version of record is available at https://www.futuremedicine.com/doi/abs/10.2217/fon-2017-0306en
dc.subjectCorticosteroidsen
dc.subjectDexamethasoneen
dc.subjectGlucocorticoidsen
dc.subjectHypomaniaen
dc.subjectManiaen
dc.subjectNeuropsychiatric adverse effectsen
dc.subjectPrednisoloneen
dc.subjectPsychiatric disorderen
dc.subjectPsychosissteroid-induced mental disorderen
dc.titleSteroid-induced mental disorders in cancer patients: a systematic reviewen
dc.typeArticle (peer-reviewed)en
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