The infant-derived bifidobacterium bifidum Strain CNCM I-4319 strengthens gut functionality

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dc.contributor.authorMartin, Rebecaen
dc.contributor.authorBottacini, Francescaen
dc.contributor.authorEgan, Muireannen
dc.contributor.authorChamignon, Celiaen
dc.contributor.authorTondereau, Valérieen
dc.contributor.authorMoriez, Raphaëlen
dc.contributor.authorKnol, Janen
dc.contributor.authorLangella, Philippeen
dc.contributor.authorEutamene, Hélèneen
dc.contributor.authorSmokvina, Tamaraen
dc.contributor.authorvan Sinderen, Douween
dc.contributor.funderDanone Nutricia Researchen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderFederation of European Microbiological Societiesen
dc.date.accessioned2023-11-28T16:14:44Z
dc.date.available2023-11-28T16:14:44Z
dc.date.issued2020en
dc.description.abstractBifidobacteria are among the first colonisers of the gastrointestinal tract of breast-fed newborns due to, among other things, their ability to metabolise oligosaccharides naturally occurring in human milk. The presence of bifidobacteria in the infant gut has been shown to promote intestinal health and homeostasis as well as to preserve a functional gut barrier, thus positively influencing host health and well-being. Among human-associated gut commensals, Bifidobacterium bifidum has been described as the only species capable of the extracellular degradation of both mucin-type glycans and HMOs, thereby giving this species a special role as a commensal gut forager of both host and diet-derived glycans. In the present study, we assess the possible beneficial properties and probiotic potential of B. bifidum strain CNCM I-4319. In silico genome analysis and growth experiments confirmed the expected ability of this strain to consume HMOs and mucin. By employing various animal models, we were also able to assess the ability of B. bifidum CNCM I-4319 to preserve gut integrity and functionality from stress-induced and inflammatory damage, thereby enforcing its potential as an effective probiotic strain.en
dc.description.sponsorshipFederation of European Microbiological Societies (Research Grant FEMS-RG-2016-0103), (ESCMID Award)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid1313en
dc.identifier.citationMartín, R., Bottacini, F., Egan, M., Chamignon, C., Tondereau, V., Moriez, R., Knol, J., Langella, P., Eutamene, H., Smokvina, T. and Van Sinderen, D. (2020) ‘The infant-derived bifidobacterium bifidum strain cncm i-4319 strengthens gut functionality’, Microorganisms, 8(9), 1313 (19pp). doi: 10.3390/microorganisms8091313en
dc.identifier.doi10.3390/microorganisms8091313en
dc.identifier.endpage19en
dc.identifier.issn2076-2607en
dc.identifier.issued9en
dc.identifier.journaltitleMicroorganismsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15269
dc.identifier.volume8en
dc.language.isoenen
dc.publisherMDPI AGen
dc.relation.ispartofMicroorganismsen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectBifidobacteriaen
dc.subjectGut microbiotaen
dc.subjectGut commensalen
dc.subjectGastrointestinal tracten
dc.subjectGut healthen
dc.titleThe infant-derived bifidobacterium bifidum Strain CNCM I-4319 strengthens gut functionalityen
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
oaire.citation.issue9en
oaire.citation.volume8en
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