Gastric aspiration and its role in airway inflammation

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dc.contributor.authorHunt, Eoin B.
dc.contributor.authorSullivan, A.
dc.contributor.authorGalvin, J.
dc.contributor.authorMacSharry, John
dc.contributor.authorMurphy, Desmond M.
dc.contributor.funderWilton Respiratory Research Fund
dc.contributor.funderDenis O’ Sullivan Fellowship award
dc.contributor.funderAPC Microbiome Institute, College of Medicine and Health, University College Cork
dc.date.accessioned2018-03-09T12:55:07Z
dc.date.available2018-03-09T12:55:07Z
dc.date.issued2018
dc.description.abstractGastro-Oesophageal Reflux (GOR) has been associated with chronic airway diseases while the passage of foreign matter into airways and lungs through aspiration has the potential to initiate a wide spectrum of pulmonary disorders. The clinical syndrome resulting from such aspiration will depend both on the quantity and nature of the aspirate as well as the individual host response. Aspiration of gastric fluids may cause damage to airway epithelium, not only because acidity is toxic to bronchial epithelial cells but also due to the effect of digestive enzymes such as pepsin and bile salts. Experimental models have shown that direct instillation of these factors to airways epithelia cause damage with a consequential inflammatory response. The pathophysiology of these responses is gradually being dissected, with better understanding of acute gastric aspiration injury, a major cause of acute lung injury, providing opportunities for therapeutic intervention and potentially, ultimately, improved understanding of the chronic airway response to aspiration. Ultimately, clarification of the inflammatory pathways which are related to micro-aspiration via pepsin and bile acid salts may eventually progress to pharmacological intervention and surgical studies to assess the clinical benefits of such therapies in driving symptom improvement or reducing disease progression.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHunt, E., Sullivan, A., Galvin, J., MacSharry, J. and Murphy, D. (2018) 'Gastric aspiration and its role in airway inflammation', Open Respiratory Medicine Journal, 12, pp.1-10. doi: 10.2174/1874306401812010001en
dc.identifier.doi10.2174/1874306401812010001
dc.identifier.endpage10
dc.identifier.issn1874-3064
dc.identifier.journaltitleOpen Respiratory Medicine Journalen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/5614
dc.identifier.volume12
dc.language.isoenen
dc.publisherBentham Openen
dc.relation.urihttps://benthamopen.com/FULLTEXT/TORMJ-12-1
dc.rights© 2018, Hunt et al. Open-Access License: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/legalcode
dc.subjectRefluxen
dc.subjectMedicineen
dc.subjectInflammationen
dc.subjectLung injuryen
dc.subjectEpitheliumen
dc.subjectCytokines.en
dc.titleGastric aspiration and its role in airway inflammationen
dc.typeArticle (peer-reviewed)en
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