Improved dietary guidelines for vitamin D: application of individual participant data (IPD)-level meta-regression analyses

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dc.contributor.authorCashman, Kevin D.
dc.contributor.authorRitz, Christian
dc.contributor.authorKiely, Mairead E.
dc.contributor.authorODIN Collaborators
dc.contributor.funderSeventh Framework Programme
dc.date.accessioned2017-06-20T11:39:43Z
dc.date.available2017-06-20T11:39:43Z
dc.date.issued2017-05-08
dc.description.abstractDietary Reference Values (DRVs) for vitamin D have a key role in the prevention of vitamin D deficiency. However, despite adopting similar risk assessment protocols, estimates from authoritative agencies over the last 6 years have been diverse. This may have arisen from diverse approaches to data analysis. Modelling strategies for pooling of individual subject data from cognate vitamin D randomized controlled trials (RCTs) are likely to provide the most appropriate DRV estimates. Thus, the objective of the present work was to undertake the first-ever individual participant data (IPD)-level meta-regression, which is increasingly recognized as best practice, from seven winter-based RCTs (with 882 participants ranging in age from 4 to 90 years) of the vitamin D intake–serum 25-hydroxyvitamin D (25(OH)D) dose-response. Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of 25(OH)D concentrations >25, 30, and 50 nmol/L across the population are 10, 13, and 26 µg/day, respectively. In contrast, standard meta-regression analyses with aggregate data (as used by several agencies in recent years) from the same RCTs estimated that a vitamin D intake requirement of 14 µg/day would maintain 97.5% of 25(OH)D >50 nmol/L. These first IPD-derived estimates offer improved dietary recommendations for vitamin D because the underpinning modeling captures the between-person variability in response of serum 25(OH)D to vitamin D intake.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid469
dc.identifier.citationCashman, K., Ritz, C., Kiely, M. and ODIN Collaborators (2017) 'Improved dietary guidelines for Vitamin D: Application of individual participant data (IPD)-Level meta-regression analyses', Nutrients, 9(5), 469 (17pp). doi: 10.3390/nu9050469en
dc.identifier.doi10.3390/nu9050469
dc.identifier.endpage17
dc.identifier.issn2072-6643
dc.identifier.journaltitleNutrientsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/4097
dc.identifier.volume9
dc.language.isoenen
dc.publisherMDPIen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613977/EU/Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle/ODIN
dc.relation.urihttp://www.mdpi.com/2072-6643/9/5/469
dc.rights© 2017, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectVitamin D recommendationsen
dc.subjectDRVen
dc.subjectRDAen
dc.subjectEARen
dc.subjectIndividual participant data-level meta-regression analysesen
dc.titleImproved dietary guidelines for vitamin D: application of individual participant data (IPD)-level meta-regression analysesen
dc.typeArticle (peer-reviewed)en
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