Solid phantom recipe for diffuse optics in biophotonics applications: a step towards anatomically correct 3D tissue phantoms

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dc.contributor.authorSekar, Sanathana Konugolu Venkata
dc.contributor.authorPacheco, Andrea
dc.contributor.authorMartella, Pierluigi
dc.contributor.authorLi, Haiyang
dc.contributor.authorLanka, Pranav
dc.contributor.authorPifferi, Antonio
dc.contributor.authorAndersson-Engels, Stefan
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHorizon 2020en
dc.date.accessioned2019-11-19T10:18:08Z
dc.date.available2019-11-19T10:18:08Z
dc.date.issued2019-04-01
dc.description.abstractWe present a tissue mimicking optical phantom recipe to create robust well tested solid phantoms. The recipe consists of black silicone pigment (absorber), silica microspheres (scatterer) and silicone rubber (SiliGlass, bulk material). The phantom recipe was characterized over a broadband spectrum (600-1100 nm) for a wide range of optical properties (absorption 0.1-1 cm−1, reduced scattering 5-25 cm−1) that are relevant to human organs. The results of linearity show a proper scaling of optical properties as well as the absence of coupling between the absorber and scatterer at different concentrations. A reproducibility of 4% among different preparations was obtained, with a similar grade of spatial homogeneity. Finally, a 3D non-scattering mock-up phantom of an infant torso made with the same recipe bulk material (SiliGlass) was presented to project the futuristic aspect of our work that is 3D printing human organs of biomedical relevance.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid356273en
dc.identifier.citationSekar, S.K.V., Pacheco, A., Martella, P., Li, H., Lanka, P., Pifferi, A. and Andersson-Engels, S. (2019) 'Solid phantom recipe for diffuse optics in biophotonics applications: a step towards anatomically correct 3D tissue phantoms', Biomedical Optics Express, 10(4), (10pp). DOI:10.1364/BOE.10.002090en
dc.identifier.doi10.1364/BOE.10.002090en
dc.identifier.eissn2156-7085
dc.identifier.endpage2100en
dc.identifier.issued4en
dc.identifier.journaltitleBiomedical Optics Expressen
dc.identifier.startpage2090en
dc.identifier.urihttps://hdl.handle.net/10468/9057
dc.identifier.volume10en
dc.language.isoenen
dc.publisherOSA - The Optical Societyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Professorship Programme/15/RP/2828/IE/Novel applications and techniques for in vivo optical imaging and spectroscopy/en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/654148/EU/The Integrated Initiative of European Laser Research Infrastructures/LASERLAB-EUROPEen
dc.relation.urihttps://www.osapublishing.org/boe/abstract.cfm?uri=boe-10-4-2090
dc.rights© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreementen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectSolid phantomsen
dc.subjectHuman organsen
dc.subject3D printingen
dc.titleSolid phantom recipe for diffuse optics in biophotonics applications: a step towards anatomically correct 3D tissue phantomsen
dc.typeArticle (peer-reviewed)en
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