Lifestyle and pregnancy complications in polycystic ovary syndrome: The SCOPE Cohort Study
dc.contributor.author | Khomami, Mahnaz Bahri | |
dc.contributor.author | Moran, Lisa J. | |
dc.contributor.author | Kenny, Louise C. | |
dc.contributor.author | Grieger, Jessica A. | |
dc.contributor.author | Myers, Jenny | |
dc.contributor.author | Poston, Lucilla | |
dc.contributor.author | McCowan, Lesley M. E. | |
dc.contributor.author | Walker, James | |
dc.contributor.author | Dekker, Gustaaf A. | |
dc.contributor.author | Norman, Robert | |
dc.contributor.author | Roberts, Claire T. | |
dc.contributor.funder | Government of South Australia | en |
dc.contributor.funder | Foundation for Research, Science and Technology | en |
dc.contributor.funder | Health Research Council of New Zealand | en |
dc.contributor.funder | Auckland Health Foundation | en |
dc.contributor.funder | Health Research Board | en |
dc.contributor.funder | National Health Service, United Kingdom | en |
dc.contributor.funder | Biotechnology and Biological Sciences Research Council | en |
dc.contributor.funder | University of Manchester | en |
dc.contributor.funder | Kings College London | en |
dc.contributor.funder | Guy's and St Thomas' Charity | en |
dc.contributor.funder | Tommy's | en |
dc.contributor.funder | Cerebra | en |
dc.contributor.funder | University of Leeds | en |
dc.contributor.funder | National Heart Foundation of Australia | en |
dc.contributor.funder | South Australian Health and Medical Research Institute | en |
dc.contributor.funder | National Heart Foundation of Australia | en |
dc.contributor.funder | Science Foundation Ireland | en |
dc.contributor.funder | University of Adelaide | en |
dc.date.accessioned | 2019-03-11T09:49:17Z | |
dc.date.available | 2019-03-11T09:49:17Z | |
dc.date.issued | 2019-02-23 | |
dc.description.abstract | Objectives: To investigate the risk of pregnancy complications in women with and without polycystic ovary syndrome after consideration of lifestyle factors. Design: Prospective cohort. Patients and measurements: Participants (n=5628) were apparently healthy nulliparous women with singleton pregnancies from the Screening for Pregnancy Endpoints study in New Zealand, Australia, United Kingdom and Ireland. Multivariable regression models were performed assessing the association of selfâreported polycystic ovary syndrome status with pregnancy complications with consideration of lifestyle factors at the 15th week of gestation. Results: Women with polycystic ovary syndrome (n=354) were older, had a higher socioeconomic index and body mass index and were less likely to consume alcohol and smoke but more likely to do vigorous exercise and take multivitamins. In univariable analysis polycystic ovary syndrome was associated with increased risk of gestational diabetes [OR: 2.2, 95% CI: 1.2, 4.0]. In multivariable models, polycystic ovary syndrome was only significantly associated with decreased risk of large for gestational age [OR: 0.62, 95% CI: 0.40, 0.98] with a population attributable risk of 0.22%. None of the other outcomes were attributable to polycystic ovary syndrome status. Conclusions: Polycystic ovary syndrome is associated with a lower risk of large for gestational age infants. In this low risk population, the risk of pregnancy complications was not increased in women with polycystic ovary syndrome who were following a healthy lifestyle. Further studies are warranted assessing the contribution of lifestyle factors to the risk of pregnancy complications in higher risk groups of women with and without polycystic ovary syndrome. | en |
dc.description.sponsorship | Government of South Australia (Australian SCOPE study supported by the Premierâs Science and Research Fund, South Australian Government (http://www.dfeest.sa.gov.au/science- research/premiers-research-and-industry-fund); Foundation for Research, Science and Technology, New Zealand (New Enterprise Research Fund); Health Research Council (04/198); Auckland Health Foundation (Evelyn Bond Fund, Auckland District Health Board Charitable Trust); Health Research Board of Ireland (CSA/2007/2; http://www.hrb.ie); National Health Service (NHS NEAT Grant (Neat Grant FSD025)); Biotechnology and Biological Sciences Research council (www.bbsrc.ac.uk/funding; GT084); University of Manchester (University of Manchester Proof of Concept Funding); National Heart Foundation, the South Australian Department of Health and the South Australian Health and Medical Research Institute ((SACVRDP Fellowship; collaboratively funded program), (AC11S374)); National Heart Foundation, Australia (Future Leader Fellowship (101169)); University of Adelaide (Lloyd Cox Professorial Research Fellowship) | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Accepted Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Khomami, M. B., Moran, L. J., Kenny, L., Grieger, J. A., Myers, J., Poston, L., McCowan, L., Walker, J., Dekker, G., Norman, R. and Roberts, C. T. (2019) 'Lifestyle and pregnancy complications in polycystic ovary syndrome: The SCOPE Cohort Study', Clinical Endocrinology, In Press, doi: 10.1111/cen.13954 | en |
dc.identifier.doi | 10.1111/cen.13954 | |
dc.identifier.endpage | 19 | en |
dc.identifier.issn | 0300-0664 | |
dc.identifier.journaltitle | Clinical Endocrinology | en |
dc.identifier.startpage | 1 | en |
dc.identifier.uri | https://hdl.handle.net/10468/7585 | |
dc.language.iso | en | en |
dc.publisher | Wiley | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/ | en |
dc.relation.uri | https://onlinelibrary.wiley.com/doi/10.1111/cen.13954 | |
dc.rights | Š 2019 John Wiley & Sons, Inc. All rights reserved. This is the peer reviewed version of the following article: Khomami, M. B et al, (2019), Lifestyle and pregnancy complications in polycystic ovary syndrome: The SCOPE Cohort Study. Clin Endocrinol. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1111/cen.13954. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | en |
dc.subject | Birth weight | en |
dc.subject | Large for gestational age | en |
dc.subject | Preterm birth | en |
dc.subject | Gestational diabetes | en |
dc.subject | Gestational hypertension | en |
dc.subject | Lifestyle | en |
dc.subject | Polycystic ovary syndrome | en |
dc.title | Lifestyle and pregnancy complications in polycystic ovary syndrome: The SCOPE Cohort Study | en |
dc.type | Article (peer-reviewed) | en |