Lifestyle and pregnancy complications in polycystic ovary syndrome: The SCOPE Cohort Study

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dc.contributor.authorKhomami, Mahnaz Bahri
dc.contributor.authorMoran, Lisa J.
dc.contributor.authorKenny, Louise C.
dc.contributor.authorGrieger, Jessica A.
dc.contributor.authorMyers, Jenny
dc.contributor.authorPoston, Lucilla
dc.contributor.authorMcCowan, Lesley M. E.
dc.contributor.authorWalker, James
dc.contributor.authorDekker, Gustaaf A.
dc.contributor.authorNorman, Robert
dc.contributor.authorRoberts, Claire T.
dc.contributor.funderGovernment of South Australiaen
dc.contributor.funderFoundation for Research, Science and Technologyen
dc.contributor.funderHealth Research Council of New Zealanden
dc.contributor.funderAuckland Health Foundationen
dc.contributor.funderHealth Research Boarden
dc.contributor.funderNational Health Service, United Kingdomen
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen
dc.contributor.funderUniversity of Manchesteren
dc.contributor.funderKings College Londonen
dc.contributor.funderGuy's and St Thomas' Charityen
dc.contributor.funderTommy'sen
dc.contributor.funderCerebraen
dc.contributor.funderUniversity of Leedsen
dc.contributor.funderNational Heart Foundation of Australiaen
dc.contributor.funderSouth Australian Health and Medical Research Instituteen
dc.contributor.funderNational Heart Foundation of Australiaen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderUniversity of Adelaideen
dc.date.accessioned2019-03-11T09:49:17Z
dc.date.available2019-03-11T09:49:17Z
dc.date.issued2019-02-23
dc.description.abstractObjectives: To investigate the risk of pregnancy complications in women with and without polycystic ovary syndrome after consideration of lifestyle factors. Design: Prospective cohort. Patients and measurements: Participants (n=5628) were apparently healthy nulliparous women with singleton pregnancies from the Screening for Pregnancy Endpoints study in New Zealand, Australia, United Kingdom and Ireland. Multivariable regression models were performed assessing the association of self‐reported polycystic ovary syndrome status with pregnancy complications with consideration of lifestyle factors at the 15th week of gestation. Results: Women with polycystic ovary syndrome (n=354) were older, had a higher socioeconomic index and body mass index and were less likely to consume alcohol and smoke but more likely to do vigorous exercise and take multivitamins. In univariable analysis polycystic ovary syndrome was associated with increased risk of gestational diabetes [OR: 2.2, 95% CI: 1.2, 4.0]. In multivariable models, polycystic ovary syndrome was only significantly associated with decreased risk of large for gestational age [OR: 0.62, 95% CI: 0.40, 0.98] with a population attributable risk of 0.22%. None of the other outcomes were attributable to polycystic ovary syndrome status. Conclusions: Polycystic ovary syndrome is associated with a lower risk of large for gestational age infants. In this low risk population, the risk of pregnancy complications was not increased in women with polycystic ovary syndrome who were following a healthy lifestyle. Further studies are warranted assessing the contribution of lifestyle factors to the risk of pregnancy complications in higher risk groups of women with and without polycystic ovary syndrome.en
dc.description.sponsorshipGovernment of South Australia (Australian SCOPE study supported by the Premier’s Science and Research Fund, South Australian Government (http://www.dfeest.sa.gov.au/science- research/premiers-research-and-industry-fund); Foundation for Research, Science and Technology, New Zealand (New Enterprise Research Fund); Health Research Council (04/198); Auckland Health Foundation (Evelyn Bond Fund, Auckland District Health Board Charitable Trust); Health Research Board of Ireland (CSA/2007/2; http://www.hrb.ie); National Health Service (NHS NEAT Grant (Neat Grant FSD025)); Biotechnology and Biological Sciences Research council (www.bbsrc.ac.uk/funding; GT084); University of Manchester (University of Manchester Proof of Concept Funding); National Heart Foundation, the South Australian Department of Health and the South Australian Health and Medical Research Institute ((SACVRDP Fellowship; collaboratively funded program), (AC11S374)); National Heart Foundation, Australia (Future Leader Fellowship (101169)); University of Adelaide (Lloyd Cox Professorial Research Fellowship)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKhomami, M. B., Moran, L. J., Kenny, L., Grieger, J. A., Myers, J., Poston, L., McCowan, L., Walker, J., Dekker, G., Norman, R. and Roberts, C. T. (2019) 'Lifestyle and pregnancy complications in polycystic ovary syndrome: The SCOPE Cohort Study', Clinical Endocrinology, In Press, doi: 10.1111/cen.13954en
dc.identifier.doi10.1111/cen.13954
dc.identifier.endpage19en
dc.identifier.issn0300-0664
dc.identifier.journaltitleClinical Endocrinologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/7585
dc.language.isoenen
dc.publisherWileyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.relation.urihttps://onlinelibrary.wiley.com/doi/10.1111/cen.13954
dc.rightsŠ 2019 John Wiley & Sons, Inc. All rights reserved. This is the peer reviewed version of the following article: Khomami, M. B et al, (2019), Lifestyle and pregnancy complications in polycystic ovary syndrome: The SCOPE Cohort Study. Clin Endocrinol. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1111/cen.13954. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en
dc.subjectBirth weighten
dc.subjectLarge for gestational ageen
dc.subjectPreterm birthen
dc.subjectGestational diabetesen
dc.subjectGestational hypertensionen
dc.subjectLifestyleen
dc.subjectPolycystic ovary syndromeen
dc.titleLifestyle and pregnancy complications in polycystic ovary syndrome: The SCOPE Cohort Studyen
dc.typeArticle (peer-reviewed)en
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