Diagnostic efficacy across dense and non-dense breasts during digital breast tomosynthesis and ultrasound assessment for recalled women

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dc.contributor.authorHadadi, I.
dc.contributor.authorClarke, J.
dc.contributor.authorRae, W.
dc.contributor.authorMcEntee, Mark F.
dc.contributor.authorVincent, W.
dc.contributor.authorEkpo, E.
dc.date.accessioned2023-07-13T13:06:22Z
dc.date.available2023-07-13T13:06:22Z
dc.date.issued2022
dc.description.abstractBackground: To compare the diagnostic efficacy of digital breast tomosynthesis (DBT) and ultrasound across breast densities in women recalled for assessment. Methods: A total of 482 women recalled for assessment from January 2017 to December 2019 were selected for the study. Women met the inclusion criteria if they had undergone DBT, ultrasound and had confirmed biopsy results. We calculated sensitivity, specificity, PPV, and AUC for DBT and ultrasound. Results: In dense breasts, DBT showed significantly higher sensitivity than ultrasound (98.2% vs. 80%; p < 0.001), but lower specificity (15.4% vs. 55%; p < 0.001), PPV (61.3% vs. 71%; p = 0.04) and AUC (0.568 vs. 0.671; p = 0.001). In non-dense breasts, DBT showed significantly higher sensitivity than ultrasound (99.2% vs. 84%; p < 0.001), but no differences in specificity (22% vs. 33%; p = 0.14), PPV (69.2% vs. 68.8%; p = 0.93) or AUC (0.606 vs. 0.583; p = 0.57). Around 73% (74% dense and 71% non-dense) and 77% (81% dense and 72% non-dense) of lesions assigned a RANZCR 3 by DBT and ultrasound, respectively, were benign. Conclusion: DBT has higher sensitivity, but lower specificity and PPV than ultrasound in women with dense breasts recalled for assessment. Most lesions rated RANZCR 3 on DBT and ultrasound are benign and may benefit from short interval follow-up rather than biopsy. � 2022 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHadadi, I., Clarke, J., Rae, W., McEntee, M., Vincent, W. and Ekpo, E. (2022) 'Diagnostic efficacy across dense and non-dense breasts during digital breast tomosynthesis and ultrasound assessment for recalled women', Diagnostics, 12(6), 1477 (13pp) doi: 10.3390/diagnostics12061477en
dc.identifier.doi10.3390/diagnostics12061477
dc.identifier.issn20754418
dc.identifier.issued6
dc.identifier.journaltitleDiagnosticsen
dc.identifier.urihttps://hdl.handle.net/10468/14732
dc.identifier.volume12
dc.language.isoenen
dc.publisherMDPIen
dc.rights© 2022, the Authors. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBreast canceren
dc.subjectBreast densityen
dc.subjectDBTen
dc.subjectEquivocal (RANZCR 3)en
dc.subjectUltrasounden
dc.titleDiagnostic efficacy across dense and non-dense breasts during digital breast tomosynthesis and ultrasound assessment for recalled womenen
dc.typeArticle (peer-reviewed)en
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