Waist circumference and risk of liver cancer: a systematic review and meta-analysis of over 2 million cohort study participants

dc.contributor.authorRahmani, J.
dc.contributor.authorKord Varkaneh, H.
dc.contributor.authorKontogiannis, V.
dc.contributor.authorRyan, Paul M.
dc.contributor.authorBawadi, H.
dc.contributor.authorFatahi, S.
dc.contributor.authorZhang, Y.
dc.date.accessioned2019-10-26T06:39:27Z
dc.date.available2019-10-26T06:39:27Z
dc.date.issued2019-10-08
dc.description.abstractPurpose: Liver cancer is the sixth most common type of cancer worldwide, and waist circumference (WC) is associated with its risk beyond body mass index (BMI). This dose-response meta-analysis was performed to investigate the association between WC and the risk of incident liver cancer using prospective cohort studies. Methods: A comprehensive systematic search was conducted in MEDLINE/PubMed, Web of Science databases, Scopus, and Coch­rane from inception to May 2019. Studies with retrospective or prospective cohort design that reported hazard ratio (HR), risk ratio, or odds ratio, and the corresponding 95% confidence intervals (CI) for liver cancer based on WC categories were included in this meta-analysis. Combined HRs with 95% CIs was estimated by DerSimonian and Laird random-effects models. Results: Associations between WC and liver cancer were reported in 5 articles with 2,547,188 participants. All studies were published between 2013 and 2019. Pooled results showed a strong significant association with minimum heterogeneity between WC and risk of liver cancer (HR 1.59, 95% CI 1.38–1.83, pheterogeneity = 0.42: I2 = 0%). Moreover, a dose-response model indicated a significant positive association between WC and risk of liver cancer (exp(b) = 1.018, p < 0.001). Conclusions: This systematic review and dose-response meta-analysis highlights WC as a significant risk factor related to the incidence of liver cancer.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRahmani, J., Kord Varkaneh, H., Kontogiannis, V., Ryan, P. M., Bawadi, H., Fatahi, S. and Zhang, Y. (2019) 'Waist Circumference and Risk of Liver Cancer: A Systematic Review and Meta-Analysis of over 2 Million Cohort Study Participants', Liver Cancer. (9pp.) [In print] DOI: 10.1159/000502478en
dc.identifier.doi10.1159/000502478en
dc.identifier.eissn1664-5553
dc.identifier.endpage9en
dc.identifier.issn2235-1795
dc.identifier.journaltitleLiver Canceren
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8870
dc.language.isoenen
dc.publisherKargeren
dc.relation.urihttps://www.karger.com/Article/FullText/502478
dc.rights©2019 The Author(s) Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectLiver canceren
dc.subjectWaist circumferenceen
dc.subjectCentral obesityen
dc.titleWaist circumference and risk of liver cancer: a systematic review and meta-analysis of over 2 million cohort study participantsen
dc.typeArticle (peer-reviewed)en
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